Comparative evaluation of two commercial PET scanners, ECAT EXACT HR+ and Biograph 2, using GATE

dc.contributor.author	Καρακατσάνης, Νικόλας	el
dc.contributor.author	Σακελλιός, Ν.	el
dc.contributor.author	Τσαντίλας, Ν.	el
dc.contributor.author	Δικαίος, Νικόλαος	el
dc.contributor.author	Τσούμπας, Χαράλαμπος	el
dc.date.accessioned	2015-01-22T11:38:26Z
dc.date.available	2015-01-22T11:38:26Z
dc.date.issued	2015-01-22
dc.identifier.uri	http://hdl.handle.net/11400/4531
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.elsevier.com	en
dc.subject	Validation
dc.subject	Monte Carlo simulations
dc.subject	Επικύρωση
dc.subject	Προσομοιώσεις Μόντε Κάρλο
dc.title	Comparative evaluation of two commercial PET scanners, ECAT EXACT HR+ and Biograph 2, using GATE	en
heal.type	journalArticle
heal.generalDescription	Proceedings of the 3rd International Conference on Imaging Technologies in Biomedical Sciences -Innovation in Nuclear and Radiological Imaging: from Basic Research to Clinical Application	en
heal.classification	Medicine
heal.classification	Physics
heal.classification	Ιατρική
heal.classification	Φυσική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://skos.um.es/unescothes/C02994
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Φυσική
heal.contributorName	Lazaro, D.	en
heal.contributorName	Λουντός, Γεώργιος	el
heal.contributorName	Schmidtlein, C.R.	en
heal.contributorName	Λουίτζη, Κ.	el
heal.contributorName	Βαλαής, Ιωάννης Γ.	el
heal.contributorName	Νικολόπουλος, Δημήτριος Σ.	el
heal.contributorName	Μαλαμίτση, Τζούλια	el
heal.contributorName	Κανδαράκης, Ιωάννης Σ.	el
heal.contributorName	Νικήτα, Κωνσταντίνα Σ.	el
heal.identifier.secondary	doi:10.1016/j.nima.2006.08.110
heal.language	en
heal.access	free
heal.recordProvider	Τ.Ε.Ι. Αθήνας. Σχολή Τεχνολογικών Εφαρμογών. Τμήμα Μηχανικών Βιοϊατρικής Τεχνολογίας Τ.Ε.	el
heal.publicationDate	2006
heal.bibliographicCitation	Karakatsanis, N., Sakellios, N., Tsantilas, N., Dikaios, N., Tsoumpas, C., et al. (December 2006). Comparative evaluation of two commercial PET scanners, ECAT EXACT HR+ and Biograph 2, using GATE. Nuclear Instruments and Methods in Physics Research A. 569(2). pp. 368–372. Elsevier Science Ltd. Available from: http://www.sciencedirect.com [Accessed 22/09/2006]	en
heal.abstract	Geant4 application for tomographic emission (GATE) is a generic Monte Carlo simulation platform based on a general-purpose code GEANT4 and designed to simulate positron emission tomography (PET) and single photon emission tomography systems. Monte Carlo simulations are used in nuclear medicine to model imaging systems and develop and assess tomographic reconstruction algorithms and correction methods for improved image quantification. The purpose of this study is to validate two GATE models of the commercial available PET scanner HR+ and the PET/CT Biograph 2. The geometry of the system components has been described in GATE, including detector ring, crystal blocks, PMTs etc. The energy and spatial resolution of the scanners as given by the manufacturers have been taken into account. The GATE simulated results are compared directly to experimental data obtained using a number of NEMA NU-2-2001 performance protocols, including spatial resolution, sensitivity and scatter fraction. All the respective phantoms are precisely modeled. Furthermore, an approximate dead-time model both at the level of single and coincidence events was developed so that the simulated count rate curve can satisfactorily match the experimental count rate performance curve for each scanner In addition a software tool was developed to build the sinograms from the simulated data and import them into the software for tomographic image reconstruction where the reconstruction algorithm of FBP3DRP was applied. An agreement of less than 0.8 mm was obtained between the spatial resolution of the simulated system and the experimental results. Also the simulated scatter fraction for the NEMA NU 2-2001 scatter phantom matched the experimental results to within 3% of measured values. Finally the ratio of the simulated sensitivities with sources radially offset 0 and 10 cm from the central axis of each of the two scanners reaches an agreement of less than 1% between the simulated and experimental values. This simulation code will be used in a second phase in order to study scatter phenomena and motion artifacts. The simulation results will be used to optimize image reconstruction algorithms, with emphasis on dynamic PET studies.	en
heal.publisher	Elsevier Science Ltd	en
heal.journalName	Nuclear Instruments and Methods in Physics Research A	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true