Molecular imaging through 1H MRS and MRSI in everyday routine: improvements in various clinical applications and parameter optimization of spectroscopic imaging sequences

dc.contributor.author	Καρατόπης, Αναστάσιος	el
dc.contributor.author	Μπενέκος, Οδυσσέας	el
dc.contributor.author	Ευσταθόπουλος, Ευστάθιος Π.	el
dc.contributor.author	Βαλαής, Ιωάννης Γ.	el
dc.contributor.author	Κανδαράκης, Ιωάννης Σ.	el
dc.date.accessioned	2015-01-22T17:49:29Z
dc.date.available	2015-01-22T17:49:29Z
dc.date.issued	2015-01-22
dc.identifier.uri	http://hdl.handle.net/11400/4559
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.elsevier.com	en
dc.subject	Acquisition optimization
dc.subject	Spectrum processing
dc.subject	Εξαγορά βελτιστοποίησης
dc.subject	Επεξεργασία φάσματος
dc.title	Molecular imaging through 1H MRS and MRSI in everyday routine: improvements in various clinical applications and parameter optimization of spectroscopic imaging sequences	en
heal.type	journalArticle
heal.generalDescription	Proceedings of the 1st International Conference on Molecular Imaging Technology-EuroMedIm 2006	en
heal.classification	Medicine
heal.classification	Physics
heal.classification	Ιατρική
heal.classification	Φυσική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://skos.um.es/unescothes/C02994
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Φυσική
heal.contributorName	Κελέκης, Νικόλαος	el
heal.identifier.secondary	doi:10.1016/j.nima.2006.10.144
heal.language	en
heal.access	free
heal.recordProvider	Τ.Ε.Ι. Αθήνας. Σχολή Τεχνολογικών Εφαρμογών. Τμήμα Μηχανικών Βιοϊατρικής Τεχνολογίας Τ.Ε.	el
heal.publicationDate	2007
heal.bibliographicCitation	Karatopis, A., Benekos, O., Efstathopoulos, E., Valais, I., Kandarakis, I., et al. (February 2007). Molecular imaging through 1H MRS and MRSI in everyday routine: Improvements in various clinical applications and parameter optimization of spectroscopic imaging sequences. Nuclear Instruments and Methods in Physics Research A. 571(1-2). pp. 502–505. Elsevier Science Ltd. Available from: http://www.sciencedirect.com [Accessed 16/11/2006]	en
heal.abstract	In the era of molecular imaging, in vivo 1H magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) are impacting dramatically upon virtually all areas of clinical medicine. MRS and MRSI should be able to identify key biochemical changes, much before the tumour becomes detectable by other functional imaging methods that mainly rely upon single markers that are not entirely sensitive or specific for malignant activity. Combined with other imaging techniques a rapidly advancing modality like MRI offer the ability to estimate the presence of metabolites yields much information regarding tissue. Molecular imaging through magnetic resonance could be potentially suited for screening and repeated monitoring since it entails no exposure to ionizing radiation. Incorporation of these tools in clinical practice is, however, limited due to the considerable amount of user intervention. In this work, various acquisition parameters and their effects in spectrum quality are investigated. In order to assess the quality of various spectroscopic techniques (2D and multi-slice MRSI, multiple echo SI), a series of experiments were conducted using a standard solution. The application of water and fat suppression techniques and their compatibility with other parameters were also investigated. The stability of the equipment, the appearance of errors and artifacts and the reproducibility of the results were also examined to obtain useful conclusions for the interaction of acquisition parameters. All the data were processed with specialized computer software (jMRUI 2.2) to analyze various aspects of the measurements and quantify various parameters such as signal-to-noise ratio (SNR), full-width at half-maximum (FWHM), peak height and j-modulation. The experience acquired from the conducted experiments was successfully applied in acquisition parameter optimization and improvement of clinical applications (two dimensional (2D) MRSI of prostate, brain and muscle MRS) by significantly improving the spectrum quality, SNR (up to 75%), spatial resolution in 2D MRSI, water and fat suppression and in some cases reducing exam times (up to 60%).	en
heal.publisher	Elsevier Science Ltd	en
heal.journalName	Nuclear Instruments and Methods in Physics Research A	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true