Nasal drug delivery in pharmaceutical and biotechnology

dc.contributor.author	Putheti, Ramesh R.	en
dc.contributor.author	Patil, Mahesh C.	en
dc.contributor.author	Obire, Omokaro	en
dc.date.accessioned	2015-01-28T20:44:47Z
dc.date.available	2015-01-28T20:44:47Z
dc.date.issued	2015-01-28
dc.identifier.uri	http://hdl.handle.net/11400/4978
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://e-jst.teiath.gr/	en
dc.subject	Parenteral route
dc.subject	Παρεντερική οδός
dc.subject	Nasal drug delivery
dc.subject	Pharmaceutical and biopharmaceutical
dc.subject	Drug delivery
dc.subject	Ρινική χορήγηση φαρμάκου
dc.subject	Φαρμακευτική και βιοφαρμακευτική
dc.subject	Διανομή φαρμάκου
dc.title	Nasal drug delivery in pharmaceutical and biotechnology	en
heal.type	journalArticle
heal.secondaryTitle	Νερατζής, Ηλίας	en
heal.classification	Medicine
heal.classification	Therapeutics
heal.classification	Ιατρική
heal.classification	Θεραπευτική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	N/A-Therapeutics
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Θεραπευτική
heal.language	en
heal.access	free
heal.publicationDate	2009
heal.bibliographicCitation	Putheti, R.R., Patil, M.C. and Obire, O. (2009). Nasal drug delivery in pharmaceutical and biotechnology: present and future. "e-Journal of Science & Technology". [Online] 4(3): 1-21. Available from: http://e-jst.teiath.gr/	en
heal.abstract	For many years, drugs have been administered intranasally for their local effect on the mucosa ( e.g. Antihistamines, decongestant, vasoconstrictors and antibiotics). In more recent years many drugs have been shown to achieve a better systemic bioavailability by self medication through the nasal route than by oral administration. Some of them have been shown to duplicate the plasma profile as i.v. administration. More recently the intranasal route has aroused increasing interest as means of the systemic administration of vaccine, hormones, peptides and certain other drugs. Although traditional nasal drug delivery methods offer significant advantages over injection or oral administration, they face challenges that limit efficacy and applications. Once relegated to treating conditions such as nasal congestion and rhinitis, intranasal drug delivery is now gaining attention for administration of a wide range of pharmaceuticals. Pharmaceutical industries are looking at nasal drug-delivery options as a viable alternative to traditional routes of administration for systemic drugs. This is due to the high permeability of the nasal epithelium, allowing a higher molecular mass cut-off at approximately 1000 Da, and the rapid drug absorption rate with plasma drug profiles sometimes almost identical to those from intravenous injections. In this review, discuss the history of overall nasal drug delivery in the pharmaceutical and biotech industries at present and suggestions for the future.	en
heal.publisher	Εκδόσεις ΤΕΙ Αθήνας	el
heal.publisher	Σιανούδης, Ιωάννης	el
heal.journalName	e-Journal of Science & Technology	en
heal.journalName	e-Περιοδικό Επιστήμης & Τεχνολογίας	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true