Cardiac functional remodeling indices in acute experimental infarction under the influence of inotropic agents

dc.contributor.author	Χανιώτης, Δημήτριος Ι.	el
dc.contributor.author	Παπαδημητρίου, Ευάγγελος Α.	el
dc.contributor.author	Γαλάνη-Τριανταφυλλίδου, Σταυρούλα Γ.	el
dc.contributor.author	Πετρόπουλος, Πέτρος Γ.	el
dc.contributor.author	Ευτυχίδου, Ελένη Π.	el
dc.date.accessioned	2015-01-29T07:02:02Z
dc.date.available	2015-01-29T07:02:02Z
dc.date.issued	2015-01-29
dc.identifier.uri	http://hdl.handle.net/11400/4996
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://e-jst.teiath.gr/	en
dc.subject	Coronary artery ligation
dc.subject	Απολίνωση της στεφανιαίας αρτηρίας
dc.subject	Experimental infarction
dc.subject	Ventricular geometry
dc.subject	Cardiac remodelling
dc.subject	Function index
dc.subject	Dobutamine infusion
dc.subject	Echocardiography
dc.subject	Κοιλιακή γεωμετρία
dc.subject	Καρδιακή ανακατασκευή
dc.subject	Δείκτης λειτουργίας
dc.subject	Έγχυση δοβουταμίνης
dc.subject	Ηχοκαρδιογραφία
dc.subject	Πείραμα μυοκαρδίου
dc.title	Cardiac functional remodeling indices in acute experimental infarction under the influence of inotropic agents	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Internal medicine
heal.classification	Ιατρική
heal.classification	Εσωτερική παθολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85067347
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Εσωτερική παθολογία
heal.contributorName	Μαξιμιάδης, Μιχαήλ	el
heal.contributorName	Χανιώτης, Φραγκίσκος Ι.	el
heal.language	en
heal.access	free
heal.publicationDate	2009
heal.bibliographicCitation	Chaniotis, D.I., Papademitriou, E.A., Galani-Triantafyllidou, S.G., Petropoulos, P.G., Eftichidou, E.P., et al. (2009). Cardiac functional remodeling indices in acute experimental infarction under the influence of inotropic agents. "e-Journal of Science & Technology". [Online] 4(4): 11-19. Available from: http://e-jst.teiath.gr/	en
heal.abstract	Objective: To study the time course changes of cardiac left ventricular (LV) geometry in acute experimental infarction by coronary artery ligation under the influence of inotropic agents. Methods: Cardiac remodelling indices depicted in the LV functional geometry such as lengths of LV long axis (LongAxL) and short axis (ShortAxL), their fractional shortening (LongAxFS and ShortAxFS) and a new recommended “function index” (FI=LongAxFS/ShortAxFS) were monitored echocardiografically in 20 anesthetized swines. Measurements were obtained before (control) and during a 75 min period following left anterior descending coronary artery (LAD) ligation. Results: In the initial 11 animals studied ejection fraction (EF), LongAxFS and FI decreased significantly below control values all over the 75 min period after LAD ligation and ShortAxFS increased progressively above control values and maximized at the 45th min. In order to investigate the underlying mechanism of these changes, LAD ligation was performed under dobutamine infusion in the remaining 9 animals: EF, LongAxFS and FI failed initially into a decline and EF returned to control values at the 45th min and LongAxFS, FI at the 75th min. ShortAxFS remained unchanged vs control under dobutamine throughout the 75 min period. The changes in FI obtained under dobutamine infusion after ligation were best bivariately correlated (r=0.72, p<0.001) and independently associated in a multiple regression model (b=0.45, p<0.001) with the changes in EF. Conclusion: The echocardiography remodelling adaptation of LV functional geometry observed in acute experimental infarction consists in deterioration contractility across the LV Long Axis and in compensatory increase contractility of the Short Axis. Dobutamine infusion at a rate of 5 μg/kg/min was correcting both EF and LongAxFS and eliminating compensatory ShortAxFS changes to prevent the acute, unfavourable remodelling of the LV. Furthermore as manifested by all indices in this study, the new “function index” FI in early post myocardial infarction period predicts the complex LV functional geometry, cardiac remodelling and EF changes.	en
heal.publisher	Νερατζής, Ηλίας	el
heal.publisher	Σιανούδης, Ιωάννης	el
heal.journalName	e-Journal of Science & Technology	en
heal.journalName	e-Περιοδικό Επιστήμης & Τεχνολογίας	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true