Sodium alginate based insitu gelling system of famotidine

dc.contributor.author	Modasiya, Moin K.	en
dc.contributor.author	Prajapati, Bhupendra G.	en
dc.contributor.author	Patel, Vishnu M.	en
dc.contributor.author	Patel, Jayvadan K.	en
dc.date.accessioned	2015-01-29T08:49:24Z
dc.date.available	2015-01-29T08:49:24Z
dc.date.issued	2015-01-29
dc.identifier.uri	http://hdl.handle.net/11400/5012
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://e-jst.teiath.gr/	en
dc.subject	Pectin
dc.subject	Πηκτίνη
dc.subject	Famotidine
dc.subject	Situ gel formation
dc.subject	Mucoadhesion
dc.subject	Φαμοτιδίνη
dc.subject	Βλεννοσυγκόλληση
dc.subject	Σχηματισμός επιτόπιας γέλης
dc.title	Sodium alginate based insitu gelling system of famotidine	en
heal.type	journalArticle
heal.secondaryTitle	preparation and in-vivo characterizations	en
heal.classification	Medicine
heal.classification	Pharmacology
heal.classification	Ιατρική
heal.classification	Φαρμακολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://skos.um.es/unescothes/C02967
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Φαρμακολογία
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85099115
heal.language	en
heal.access	free
heal.publicationDate	2010
heal.bibliographicCitation	Modasiya, M.K., Prajapati, B.G., Patel, V.M. and Patel, J.K. (2010). Sodium alginate based insitu gelling system of famotidine: preparation and in-vivo characterizations. "e-Journal of Science & Technology". [Online] 5(1): 27-42. Available from: http://e-jst.teiath.gr/	en
heal.abstract	The aim of the present study was to design and evaluate in situ gelling system for oral sustained release drug delivery of Famotidine, which was selected as a model drug due to its short biological half-life (2-3 hrs) and as an H2 receptor antagonist to be released in stomach. On the basis of the preliminary trials, a 32 full factorial design was employed to study the effect of independent variables, concentration of pectin (X1) and concentration of CaCl2 (X2) on dependent variables like viscosity, drug content, Q50, Q80 and similarity factor. Main effects and interaction terms of the formulation variables could be evaluate quantitatively by a mathematical model. It was found that both the pectin and concentration of CaCl2 had significant impact on viscosity, drug content, Q50, Q80 and similarity factor (f2) of the system. In-vitro release study revealed that drug released from the insitu gel followed non-fickian diffusion. In vivo study for the selected batch of sodium alginate was carried out by pylorus legation method in rats, which showed gel formation in gastric juice and reduction in ulcer index. Stability study was also carried out for three months, which showed no major changes from their initial state.	en
heal.publisher	Νερατζής, Ηλίας	el
heal.publisher	Σιανούδης, Ιωάννης	el
heal.journalName	e-Journal of Science & Technology	en
heal.journalName	e-Περιοδικό Επιστήμης & Τεχνολογίας	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true