Formation and statistical optimization of the time controlled pulsatile release propanolol hydrochloride compressed coated tablet

dc.contributor.author	Prajapati, Bhupendra G.	en
dc.contributor.author	Patel, Girish N.	en
dc.contributor.author	Solanki, H. K.	en
dc.date.accessioned	2015-01-30T20:04:39Z
dc.date.available	2015-01-30T20:04:39Z
dc.date.issued	2015-01-30
dc.identifier.uri	http://hdl.handle.net/11400/5189
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://e-jst.teiath.gr/	en
dc.subject	Propranolol hydrochloride
dc.subject	Υδροχλωρική προπανολόλη
dc.subject	Time controlled pulsatile release
dc.subject	Compression coating
dc.subject	Χρόνος ελεγχόμενης παλμικής αποδέσμευσης
dc.subject	Συμπιεστική επικάλυψη
dc.subject	Hydroxypropyl methylcellulose
dc.subject	Υδροξυπροπυλομεθυλοκυτταρίνη
dc.subject	Ethylcellulose
dc.subject	Αιθυλοκυτταρίνη
dc.title	Formation and statistical optimization of the time controlled pulsatile release propanolol hydrochloride compressed coated tablet	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Pharmacology
heal.classification	Ιατρική
heal.classification	Φαρμακολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://skos.um.es/unescothes/C02967
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Φαρμακολογία
heal.language	en
heal.access	free
heal.publicationDate	2010
heal.bibliographicCitation	Prajapati, B.G., Patel, G.N. and Solanki, H.K. (2010). Formation and statistical optimization of the time controlled pulsatile release propanolol hydrochloride compressed coated tablet. "e-Journal of Science & Technology". [Online] 5(4): 9-19. Available from: http://e-jst.teiath.gr/	en
heal.abstract	The Purpose of present investigation was to evaluate statical influence different concentration of hydroxy propyl methyl cellulose K4M and ethyl cellulose on Propranolol hydrochloride release compression coated tablet using 32 full factorial design. Tablets were prepared by direct compression technique. Time controlled pulsatile Propranolol hydrochloride tablets containing 40 mg of Propranolol hydrochloride were developed using different ratio of hydroxypropyl methylcellulose and ethyl cellulose that retard the drug release in the physiological environment of stomach and 2-3 hr in intestine. Formulation was optimized on basis of acceptable tablet properties and in vitro drug release. To analyse the release mechanism of optimize batch zero order, first order, Higuchi, Hixson Crowell, Korsmeyer–Peppas kinetic model were used. The kinetics release of optimize batch F3 was best explained by zero order model, Hixson Crowell, and Korsmeyer–Peppas kinetic model.	en
heal.publisher	Νερατζής, Ηλίας	el
heal.publisher	Σιανούδης, Ιωάννης	el
heal.journalName	e-Journal of Science & Technology	en
heal.journalName	e-Περιοδικό Επιστήμης & Τεχνολογίας	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true