Formation, evaluation and optimization of orally disintegrating tablet of Cinnarizine

dc.contributor.author	Prajapati, Bhupendra G.	en
dc.contributor.author	Patel, Satish N.	en
dc.date.accessioned	2015-02-01T17:06:04Z
dc.date.available	2015-02-01T17:06:04Z
dc.date.issued	2015-02-01
dc.identifier.uri	http://hdl.handle.net/11400/5335
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://e-jst.teiath.gr/	en
dc.subject	Water absorption ratio
dc.subject	Αναλογία απορρόφησης νερού
dc.subject	Cinnarizine
dc.subject	Orally disintegrating tablet
dc.subject	Wetting time
dc.subject	Κινναριζίνη
dc.subject	Χρόνος διαβροχής
dc.subject	Στοματικό διαλυόμενο δισκίο
dc.title	Formation, evaluation and optimization of orally disintegrating tablet of Cinnarizine	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Pharmacology
heal.classification	Ιατρική
heal.classification	Φαρμακολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://skos.um.es/unescothes/C02967
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Φαρμακολογία
heal.language	en
heal.access	free
heal.publicationDate	2010
heal.bibliographicCitation	Prajapati, B.G. and Patel, S.N. (2010). Formation, evaluation and optimization of orally disintegrating tablet of Cinnarizine. "e-Journal of Science & Technology". [Online] 5(5): 9-21. Available from: http://e-jst.teiath.gr/	en
heal.abstract	Objective of this study was to formulate directly compressible orally disintegrating tablets of Cinnarizine with sufficient mechanical integrity, content uniformity, and acceptable palatability to assist patients of any age group for easy administration. Effect of varying concentrations of different superdisintegrants such as crospovidone, croscarmellose sodium, and sodium starch glycolate on disintegration time was studied. Tablets were evaluated for weight variation, thickness, hardness, friability, taste, drug content, in vitro disintegrating time and in vitro drug release. Other parameters such as wetting time, water absorption ratio (‘R’), and drug-excipient compatibility were also evaluated. The disintegration time of the optimized CP5 batch was 25 sec. Good correlation was observed between disintegration time and water absorption ratio (R) for each of three superdisintegrants at concentrations studied. Considering the ‘R’ values and disintegration time, crospovidone was significantly superior compared to other two superdisintegrants tested. Release of drug was faster from formulations containing 6% crospovidone (CP5) compared to the marketed convetional Cinnarizine tablet. Differential scanning calorimetric studies did not indicate any excipient incompatibility, either during mixing or after compression. Finally concluded that directly compressible orally disintegrating tablets of cinnarizine with lower friability, acceptable taste, and shorter disintegration times were obtained using crospovidone at optimized concentrations.	en
heal.publisher	Νερατζής, Ηλίας	el
heal.publisher	Σιανούδης, Ιωάννης	el
heal.journalName	e-Journal of Science & Technology	en
heal.journalName	e-Περιοδικό Επιστήμης & Τεχνολογίας	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true