Matrix sustained release tablet of water soluble prokinetic agent

dc.contributor.author	Prajapati, Bhupendra G.	en
dc.contributor.author	Patel, Niklesh	en
dc.contributor.author	Patel, Hitesh K.	en
dc.date.accessioned	2015-02-01T17:59:14Z
dc.date.available	2015-02-01T17:59:14Z
dc.date.issued	2015-02-01
dc.identifier.uri	http://hdl.handle.net/11400/5345
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://e-jst.teiath.gr/	en
dc.subject	Gastro esophageal reflux disease (GERD)
dc.subject	Γαστροοισοφαγική παλινδρόμηση
dc.subject	Itopride hydrochloride
dc.subject	Hydroxypropylmethylcellulose (HPMC)
dc.subject	Sustained release
dc.subject	Prokinetic drug
dc.subject	Υδροξυπροπυλομεθυλοκυτταρίνη (HPMC)
dc.subject	Παρατεταμένη απελευθέρωση
dc.subject	Προκινητικό φάρμακο
dc.title	Matrix sustained release tablet of water soluble prokinetic agent	en
heal.type	journalArticle
heal.secondaryTitle	itopride hydrochloride	en
heal.classification	Medicine
heal.classification	Pharmacology
heal.classification	Ιατρική
heal.classification	Φαρμακολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://skos.um.es/unescothes/C02967
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Φαρμακολογία
heal.language	en
heal.access	free
heal.publicationDate	2010
heal.bibliographicCitation	Prajapati, B.G., Patel, N. and Patel, H.K. (2010). Matrix sustained release tablet of water soluble prokinetic agent: itopride hydrochloride. "e-Journal of Science & Technology". [Online] 5(5): 67-75. Available from: http://e-jst.teiath.gr/	en
heal.abstract	Itopride hydrochloride is highly water soluble prokinetic drug that is used in the Gastro esophageal reflux disease (GERD). Aim of present investigation was formulating sustained release formulation of Itopride hydrochloride for oral drug delivery. Oral route gets the highest priority for the delivery of the drug as well as better patient compliance in case of self medication. Pregelatinized Starch, Hydroxy methyl propyl cellulose (HPMC) K4M, HPMC K100M and Ethyl Cellulose were used to control the release of the drug from the sustained release tablet. Optimization of polymers concentration that can control the release of the drug as like the hypothetical release profile was based on trial and error. Optimized batch F11 was showing good tablet properties like hardness (7-8kg/cm2), thickness (4.61mm), friability (0.061%), assay (99.3%) and nearly similar drug release profile to the hypothetical drug release profile and it was indicated by similarity factor (F2=80.25). Mathematical model application was applied to the release profile of optimized batch. The obtained value of regression coefficient was 0.9962 which indicate that formulation was following the higuchi model.	en
heal.publisher	Νερατζής, Ηλίας	el
heal.publisher	Σιανούδης, Ιωάννης	el
heal.journalName	e-Journal of Science & Technology	en
heal.journalName	e-Περιοδικό Επιστήμης & Τεχνολογίας	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true