Psychophysiological evaluation of short-term neurotoxicity after prophylactic brain irradiation in patients with small cell lung cancer

dc.contributor.author	Παπαγεωργίου, Χαράλαμπος	el
dc.contributor.author	Δαρδούφας, Κωνσταντίνος	el
dc.contributor.author	Κουλουλίας, Βασίλειος	el
dc.contributor.author	Βεντούρας, Ερρίκος Μ.	el
dc.contributor.author	Ουζούνογλου, Νικόλαος Κ.	el
dc.date.accessioned	2015-02-02T10:18:30Z
dc.date.available	2015-02-02T10:18:30Z
dc.date.issued	2015-02-02
dc.identifier.uri	http://hdl.handle.net/11400/5447
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.springer.com/gp/	en
dc.subject	Prophylactic cranial irradiation
dc.subject	Small cell lung cancer
dc.subject	Προφυλακτική κρανιακή ακτινοβολία
dc.subject	Μικροκυτταρικός καρκίνος του πνεύμονα
dc.title	Psychophysiological evaluation of short-term neurotoxicity after prophylactic brain irradiation in patients with small cell lung cancer	en
heal.type	journalArticle
heal.secondaryTitle	a study of event related potentials	en
heal.classification	Medicine
heal.classification	Cancer
heal.classification	Ιατρική
heal.classification	Καρκίνος
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://zbw.eu/stw/descriptor/18899-3
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Καρκίνος
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh86005665
heal.contributorName	Βλάχος, Λάμπρος	el
heal.contributorName	Ραμπαβίλας, Ανδρέας Ν.	el
heal.contributorName	Χριστοδούλου, Γεώργιος Ν.	el
heal.identifier.secondary	DOI 10.1023/A:1006447624574
heal.language	en
heal.access	campus
heal.recordProvider	Τ.Ε.Ι. Αθήνας. Σχολή Τεχνολογικών Εφαρμογών. Τμήμα Μηχανικών Βιοϊατρικής Τεχνολογίας Τ.Ε.	el
heal.publicationDate	2000
heal.bibliographicCitation	Papageorgiou, C., Dardoufas, C., Kouloulias, V., Ventouras, E., Uzunoglou, N., et al. (December 2000). Psychophysiological evaluation of short-term neurotoxicity after prophylactic brain irradiation in patients with small cell lung cancer: a study of event related potentials. Journal of Neuro-Oncology. 50(3). pp.275-285. Kluwer Academic Publishers: Netherlands, 2000. Available from: http://link.springer.com	en
heal.abstract	Background. The aim of this study was to show, whether a certain prophylacting applicable radiation affects the cognition, particularly, the specific cognitive components P50, N100, P300 and N400 of auditory event related potentials (ERPs) during a short memory test. Methods and materials. Eleven patients with small cell lung cancer (SCLC), who had presented complete response of disease after chemotherapy and radical radiotherapy in the lung, were prescribed to receive a prophylacting cranial irradiation (PCI) with a 6 MeV linear accelerator. The dose schedule was consisting of a total dose up to 30 Gy in 10 fractions, within 12 days (5 days a week). The psychophysiological approach before and after PCI was assessed by measurements of the auditory ERPs during a short memory performance using the digit-span Wechsler test. Components of ERP were recorded from 15 scalp electrodes. Additionally, symptomatology of depression and anxiety were assessed using Zung Self-Rating Depression Scale and Spielberger Anxiety Inventory, respectively, for pre- and post-PCI. Results. No significant difference was noticed pre- and post-radiotherapy of all particular level of psychophysiological analysis concerning both the latencies and the amplitudes of ERPs auditory components P50, N100, P300 and N400 (P > 0.05, Wilcoxon signed test). Additionally, no changes were found with regard to behavioral performance (memory recall), depression symptomatology and state anxiety, according to pre- and post-radiation measurements. However, the self-reported depression symptomatology showed that the patients presented moderate depression. Conclusion. No short-term psychophysiological neurotoxicity was detected with this PCI schedule using these instruments, lending additional support to evidence suggesting the benefit of this certain PCI schedule for patients with SCLC.	en
heal.publisher	Kluwer Academic Publishers	en
heal.journalName	Journal of Neuro-Oncology	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true