Enhancement of glipizide dissolution rate through nanoparticles

dc.contributor.author	Patel, Dhaval	en
dc.contributor.author	Chaudhary, Priyanka S.	en
dc.contributor.author	Mohan, Hiren Khatri	en
dc.date.accessioned	2015-02-07T17:37:43Z
dc.date.available	2015-02-07T17:37:43Z
dc.date.issued	2015-02-07
dc.identifier.uri	http://hdl.handle.net/11400/5802
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://e-jst.teiath.gr/	en
dc.subject	glipizide
dc.subject	Nanosuspension
dc.subject	Solubility
dc.subject	Dissolution
dc.subject	Διαλυτότητα
dc.subject	Διάλυση
dc.title	Enhancement of glipizide dissolution rate through nanoparticles	en
heal.type	journalArticle
heal.secondaryTitle	formulation and in vitro evaluation	en
heal.classification	Medicine
heal.classification	Pharmacy
heal.classification	Ιατρική
heal.classification	Φαρμακευτική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85100603
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Φαρμακευτική
heal.keywordURI	http://lod.nal.usda.gov/43050
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85124725
heal.language	en
heal.access	free
heal.publicationDate	2012
heal.bibliographicCitation	Patel, D., Chaudhary, P.S. and Mohan, H.K. (2012). Enhancement of glipizide dissolution rate through nanoparticles: formulation and in vitro evaluation. "e-Journal of Science & Technology". [Online] 7(4): 19-31. Available from: http://e-jst.teiath.gr/	en
heal.abstract	The objective of the present investigation was to enhance the solubility of practically insoluble glipizide by preparing its nanoparticles. The glipizide nanoparticles were prepared by anti-solvent precipitation method using various drug-to-stabilizers ratio. The nanoparticles of glipizide were evaluated for particle size, zeta potential, saturation solubility, and dissolution behavior. Glipizide nanoparticles showed particle size of 425.6 nm and zeta potential of −16.2 mV. Saturation solubility of pure glipizide and nanosuspension were 0.19±0.006mg/20ml and 4.3±0.18 mg/20ml respectively, showing more than 22.63 times increase in solubility. Differential scanning calorimetry (DSC) showed that crystalline state of glipizide remained unchanged in glipizide nanosuspension. In glipizide nanosuspension, 59.57±0.63% of the drug released within 10min and almost 100±0.2% within 60min, while micronized suspension of glipizide showed only 8.91±0.58% release at the end of 5min and 18.21±0.25% release in 60 min. From the results, it was concluded that significant enhancement in solubility of glipizide in phosphate buffer (pH 6.8) thus enhancement in dissolution of it when formulated as drug nanoparticles.	en
heal.publisher	Νερατζής, Ηλίας	el
heal.publisher	Σιανούδης, Ιωάννης	el
heal.journalName	e-Journal of Science & Technology	en
heal.journalName	e-Περιοδικό Επιστήμης & Τεχνολογίας	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true