Potential dangers with overuse of antioxidant enzymes as nutritional supplements

dc.contributor.author	Δελημάρης, Ιωάννης Α.	el
dc.date.accessioned	2015-02-07T18:02:46Z
dc.date.available	2015-02-07T18:02:46Z
dc.date.issued	2015-02-07
dc.identifier.uri	http://hdl.handle.net/11400/5807
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://e-jst.teiath.gr/	en
dc.subject	Diet
dc.subject	Superoxide dismutase
dc.subject	glutathione peroxidase
dc.subject	Catalase
dc.subject	Διατροφή
dc.subject	Δισμουτάση υπεροξειδίου
dc.subject	Υπεροξειδάσης γλουταθειόνης
dc.subject	Καταλάση
dc.title	Potential dangers with overuse of antioxidant enzymes as nutritional supplements	en
heal.type	journalArticle
heal.secondaryTitle	how much have we revealed?	en
heal.classification	Technology
heal.classification	Chemical technology
heal.classification	Τεχνολογία
heal.classification	Χημική τεχνολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85133147
heal.classificationURI	http://skos.um.es/unescothes/C00565
heal.classificationURI	N/A-Τεχνολογία
heal.classificationURI	N/A-Χημική τεχνολογία
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85130641
heal.keywordURI	http://lod.nal.usda.gov/35248
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85020809
heal.language	en
heal.access	free
heal.publicationDate	2012
heal.bibliographicCitation	Delimaris, I.A. (2012). Potential dangers with overuse of antioxidant enzymes as nutritional supplements: how much have we revealed?. "e-Journal of Science & Technology". [Online] 7(4): 49-54. Available from: http://e-jst.teiath.gr/	en
heal.abstract	OBJECTIVE: Even though it is known that antioxidants can be obtained from food (mainly fruits and vegetables) the consumption of antioxidant supplements in the general population is broad in extent. The results of epidemiological studies where people were treated with antioxidant supplements are inconclusive and contradictory; however, they are numerous and comprise an intensive field of research. Less is known about the supplementation of antioxidant enzymes because randomized clinical trials are limited, and the potential harmful effects of their overconsumption have only recently started to be investigated. The aim of this brief review is to investigate the potential dangers of antioxidant enzymes overuse (high doses obtained from artificial oral supplements or intravenous infusion ) on people's health status. METHODS: Original articles were searched via the online databases PubMed and Google Scholar published between 1990 and 2012. RESULTS: Data indicate that high doses of supplementary antioxidant enzymes could act as doubleedged swords in cellular redox state as they present health beneficial effects at physiologic doses versus deleterious effects at high doses. Since randomized clinical trials with regard to antioxidant enzymes are scarce there is no official recommended dosage, and if the dose is set too high, safety problems are likely to result. Excessive antioxidant action could adversely affect key physiological processes. CONCLUSIONS: The use of antioxidant enzymes is not an alternative to regular consumption of fruits and vegetables. Antioxidant compounds within fruits and vegetables may be considered as being more safe and healthy compared to isolated, high doses, such as present in nutritional supplements. Further evidence-based research should focus on the need to answer the questions regarding what effects dose and environment have on pro-oxidant/antioxidant mechanisms before recommending nutritional supplement interventions with antioxidant enzymes.	en
heal.publisher	Νερατζής, Ηλίας	el
heal.publisher	Σιανούδης, Ιωάννης	el
heal.journalName	e-Journal of Science & Technology	en
heal.journalName	e-Περιοδικό Επιστήμης & Τεχνολογίας	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true