In vitro and invivo drug-drug interaction study between ketotifen fumerate and chlorpheniramine maleate at gastric and intestinal pH

dc.contributor.author	Sayeed, Mohammed Aktar	en
dc.contributor.author	Rana, Sohel	en
dc.date.accessioned	2015-02-09T19:50:47Z
dc.date.available	2015-02-09T19:50:47Z
dc.date.issued	2015-02-09
dc.identifier.uri	http://hdl.handle.net/11400/5943
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://e-jst.teiath.gr/	en
dc.subject	Ketotifen fumerate
dc.subject	Chlorpheniramine maleate
dc.subject	Job's method
dc.subject	Ardon's method
dc.subject	Stability constant values
dc.subject	Μηλεϊνική χλωροφαινιραμίνη
dc.subject	Μέθοδος του Ιώβ
dc.subject	Μέθοδος του Ardon
dc.title	In vitro and invivo drug-drug interaction study between ketotifen fumerate and chlorpheniramine maleate at gastric and intestinal pH	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Pharmacy
heal.classification	Ιατρική
heal.classification	Φαρμακευτική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85100603
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Φαρμακευτική
heal.language	en
heal.access	free
heal.publicationDate	2013
heal.bibliographicCitation	Sayeed, M.A. and Rana, S. (2013). In vitro and invivo drug-drug interaction study between ketotifen fumerate and chlorpheniramine maleate at gastric and intestinal pH. "e-Journal of Science & Technology". [Online] 8(2): 17-25. Available from: http://e-jst.teiath.gr/	en
heal.abstract	The use of two or more drugs in the same prescription is a common practice for the treatment of a patient, which may sometimes be neither safe nor effective. The main aim of the present study was to find out invitro and invivo drug- drug interaction study between ketotifen fumerate and chlorpheniramine maleate in aqueous media at various pH (1.2, 2.8 and 6.8) by using Job‟s continuous-variation analysis and Ardon‟s spectrophotomeric methods. The stability constant values of chlorpheniramine with ketotifen were determined at a fixed temperature (37 0C) at both gastric and intestinal pH. The stability constant values , ranging between 7.79 and 8.21 when ketotifen fumerate and chlorpheniramine maleate were the drug of choice, were derived from Ardon‟s plot as a result of interaction between the drugs, were comparatively stable. However, after interaction it was observed that, stability constant values were more than 1 at both gastric pH (1.2 and 2.8) and intestinal pH (6.8). The in vivo study indicate that the decrease in concentration of ketotifen after concurrent administration of ketotifen and chlorpheniramine was statistically insignificant.	en
heal.publisher	Νερατζής, Ηλίας	el
heal.publisher	Σιανούδης, Ιωάννης	el
heal.journalName	e-Journal of Science & Technology	en
heal.journalName	e-Journal of Science & Technology	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true