Metformin hydrochloride sustained release tablet using different matrixing tablet

dc.contributor.author	Prajapati, Bhupendra G.	en
dc.contributor.author	Patel, Rakesh P.	en
dc.contributor.author	Patel, Dhaval	en
dc.contributor.author	Shah, Payal	en
dc.date.accessioned	2015-02-12T00:20:11Z
dc.date.available	2015-02-12T00:20:11Z
dc.date.issued	2015-02-12
dc.identifier.uri	http://hdl.handle.net/11400/6084
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://e-jst.teiath.gr/	en
dc.subject	Sustained release drug delivery system
dc.subject	Matrix tablets
dc.subject	Metformin hydrochloride
dc.subject	HPMC
dc.subject	Παρατεταμένη απελευθέρωση συστήματος χορήγησης φαρμάκων
dc.subject	Υδροχλωρική μετφορμίνη
dc.title	Metformin hydrochloride sustained release tablet using different matrixing tablet	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Pharmacy
heal.classification	Ιατρική
heal.classification	Φαρμακευτική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85100603
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Φαρμακευτική
heal.language	en
heal.access	free
heal.publicationDate	2013
heal.bibliographicCitation	Prajapati, B.G., Patel, R.P., Patel, D. and Shah, P. (2013). Metformin hydrochloride sustained release tablet using different matrixing tablet. "e-Journal of Science & Technology". [Online] 8(4): 61-72. Available from: http://e-jst.teiath.gr/	en
heal.abstract	Sustained release dosage forms continue to draw attention in the search for improved patient compliance & decreased incidences of adverse drug reactions. The objective of this work was to prepare & evaluate sustained release matrix tablets of Metformin HCl using different polymers. Metformin HCl is a water soluble drug indicated to improve glycemic control in patients with type II diabetes. Metformin HCl Matrix tablets were prepared using different polymers like Carbopol 971, Xanthan gum, hydroxypropyl methyl cellulose K100M, Carbopol 71G by wet granulation technique. Prepared tablets were evaluated for weight variation test, hardness, friability, uniformity of content, assay & in vitro drug release. Influence of different parameters like pH, agitation intensity on drug release was studied for optimized batch. Metformin HCl sustained release matrix tablets prepared using HPMC K100M was found to have higher drug content 99±0.5 % w/w & better drug release profile 95±3 % after 12 hrs & hence it was optimized. In vitro release profile of optimized formulations was found to be similar to that of commercial marketed products. The average f2 values were found to be 56.47 for matrix tablets. Likewise other water soluble drugs can also be formulated for sustained release matrix system.	en
heal.publisher	Νερατζής, Ηλίας	el
heal.publisher	Σιανούδης, Ιωάννης	el
heal.journalName	e-Journal of Science & Technology	en
heal.journalName	e-Περιοδικό Επιστήμης & Τεχνολογίας	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true