Formulation, in-vitro and in-vivo X-ray evaluation of sustained release matrix tablets of Diltiazem HCL using hydrophilic hydrophobic polymer blend

dc.contributor.author	Merekar, Abhijit N.	en
dc.contributor.author	Kuchekar, Bhanudas S.	en
dc.date.accessioned	2015-02-14T09:26:30Z
dc.date.available	2015-02-14T09:26:30Z
dc.date.issued	2015-02-14
dc.identifier.uri	http://hdl.handle.net/11400/6192
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://e-jst.teiath.gr/	en
dc.subject	Diltiazem Hydrochloride
dc.subject	HPMC K100LV
dc.subject	Eudragit L100-55
dc.subject	X-ray
dc.subject	SR Matrix tablets
dc.subject	Drug delivery systems
dc.subject	Υδροχλωρική διλτιαζέμη
dc.subject	Ακτίνα Χ
dc.subject	Συστήματα παροχής φαρμάκου
dc.title	Formulation, in-vitro and in-vivo X-ray evaluation of sustained release matrix tablets of Diltiazem HCL using hydrophilic hydrophobic polymer blend	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Pharmacy
heal.classification	Ιατρική
heal.classification	Φαρμακευτική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85100603
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Φαρμακευτική
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh88007108
heal.language	en
heal.access	free
heal.publicationDate	2013
heal.bibliographicCitation	Merekar, A.N. and Kuchekar, B.S. (2013). Formulation, in-vitro and in-vivo X-ray evaluation of sustained release matrix tablets of Diltiazem HCL using hydrophilic hydrophobic polymer blend. "e-Journal of Science & Technology". [Online] 8(5): 1-15. Available from: http://e-jst.teiath.gr/	en
heal.abstract	The SR matrix tablets were formulated by directly compressible hydrophilic hydrophobic polymeric blend of HPMC K100LV and Eudragit L100-55. Here Diltiazem hydrochloride was used as model drug. Tablets were prepared by direct compression method. The pre and post compression parameters were evaluated. Drug polymer interaction was checked by comparing the FTIR spectra of the physical mixture of drug with the excipients used with pure drug. This established the stability of the drug in the formulation which was further confirmed by Differential Scanning Calorimetry thermograms. Formulation was optimized on the basis of acceptable tablet properties and in vitro drug release. The results of dissolution studies indicated that formulation F11 the most successful of the study, exhibited drug release pattern very close to marketed product release profile. The mechanism of drug release from F11 was diffusion coupled with erosion (anomalous). Scanning electron microscopy was used to visualize the effect of dissolution medium on matrix tablet surface. In vivo X-ray studies were conducted by X-ray analysis which shows sustaining activity by adhering to various sites in the gastrointestinal tract. The long term stability results show no significant change in the dissolution profile. In conclusion, SR matrix tablet formulation is successfully formulated which can lead to improve efficacy and better patient compliance.	en
heal.publisher	Νερατζής, Ηλίας	el
heal.publisher	Σιανούδης, Ιωάννης	el
heal.journalName	e-Journal of Science & Technology	en
heal.journalName	e-Περιοδικό Επιστήμης & Τεχνολογίας	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true