X-Ray spectra optimization for the Hydroxyapatite/Collagen ratio determination

dc.contributor.author	Μαρτίνη, Νίκη Δ.	el
dc.contributor.author	Φούντος, Γεώργιος Π.	el
dc.contributor.author	Κούκου, Βάϊα Ν.	el
dc.contributor.author	Σωτηροπούλου, Παναγιώτα Ι.	el
dc.contributor.author	Μιχαήλ, Χρήστος Μ.	el
dc.date.accessioned	2015-02-14T14:57:22Z
dc.date.available	2015-02-14T14:57:22Z
dc.date.issued	2015-02-14
dc.identifier.uri	http://hdl.handle.net/11400/6250
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://e-jst.teiath.gr/	en
dc.subject	Osteoporosis
dc.subject	CV
dc.subject	HAp/Col ratio
dc.subject	Low bone mass
dc.subject	Nuclear medicine
dc.subject	Οστεοπόρωση
dc.subject	Χαμηλή οστική μάζα
dc.subject	Πυρηνική ιατρική
dc.title	X-Ray spectra optimization for the Hydroxyapatite/Collagen ratio determination	en
heal.type	journalArticle
heal.secondaryTitle	a new approach in osteoporosis diagnosis	en
heal.classification	Medicine
heal.classification	Medical physics
heal.classification	Ιατρική
heal.classification	Ιατρική φυσική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85083001
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Ιατρική φυσική
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85095984
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85093011
heal.contributorName	Μπάκας, Αθανάσιος	el
heal.contributorName	Κανδαράκης, Ιωάννης Σ.	el
heal.contributorName	Νικηφορίδης, Γεώργιος Χ.	el
heal.language	en
heal.access	free
heal.publicationDate	2014
heal.bibliographicCitation	Martini, N.D., Fountos, G.P., Koukou, V.N., Sotiropoulou, P.I., Michail, C.M., et al. (2014). X-Ray spectra optimization for the Hydroxyapatite/Collagen ratio determination: a new approach in osteoporosis diagnosis. "e-Journal of Science & Technology". [Online] 9(3): 29-34. Available from: http://e-jst.teiath.gr/	en
heal.abstract	The Dual energy method, using two different energies generated by an X-ray tube, has been applied in the diagnosis of osteoporosis by determining bone mass or bone density. By measuring parameters that characterize bone quality, such as the Ca/P or Hydroxyapatite/Collagen (HAp/Col) ratios, a potential bone fracture can be predicted more efficiently. The aim of this study was the optimization of dual energy X-ray spectra through the estimation of the Coefficient of Variation (CV) in HAp/Col ratio determination. The upper limit of CVHAp/Col value was set to ≤ 3%. Single and double exposure methods were used in order to obtain polyenergetic spectra. Unfiltered spectra were obtained from Boone et al (1997 Med. Phys. 24 1661–70) for Tungsten (W) anode. For the implementation of the low and high energy beams, several filters were applied to the spectra, based on their K-edges, so as to provide quasi-monochromatic beams. The optimum results, for the single exposure method, were obtained for a 120kVp spectrum with added beam filtration of 800um Ce (CVHAp/Col=1.88%). For the double exposure technique, a CVHAp/Col value of 2.23% was obtained using 40 and 120kVp with added filtration of 250um Cd and 1150um Yb, respectively.	en
heal.publisher	Νερατζής, Ηλίας	el
heal.publisher	Σιανούδης, Ιωάννης	el
heal.journalName	e-Journal of Science & Technology	en
heal.journalName	e-Περιοδικό Επιστήμης & Τεχνολογίας	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true