Value of individualized dosimetry in peptide receptor radionuclide therapy (PRRT) by Lutetium-177 [177lu – Dota0, Tyr3] octreotate

dc.contributor.author	Μπάκα, Ειρήνη	el
dc.contributor.author	Πλούση, Αγάπη	el
dc.contributor.author	Αργυρού, Μαρία	el
dc.contributor.author	Βαλάση, Αλεξία	el
dc.contributor.author	Λιμούρης, Γεώργιος Σ.	el
dc.date.accessioned	2015-02-14T15:30:13Z
dc.date.available	2015-02-14T15:30:13Z
dc.date.issued	2015-02-14
dc.identifier.uri	http://hdl.handle.net/11400/6254
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://e-jst.teiath.gr/	en
dc.subject	Individualized Dosimetry
dc.subject	177Lu-DOTA-octreotate
dc.subject	Neuroendocrine tumors
dc.subject	Peptide
dc.subject	Receptor Radiotherapy
dc.subject	Nuclear medicine
dc.subject	Εξατομικευμένη Δοσιμετρία
dc.subject	Νευροενδοκρινείς όγκοι
dc.subject	Πεπτίδιο
dc.subject	Ακτινοθεραπεία Υποδοχέων
dc.subject	Πυρηνική ιατρική
dc.title	Value of individualized dosimetry in peptide receptor radionuclide therapy (PRRT) by Lutetium-177 [177lu – Dota0, Tyr3] octreotate	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Medical physics
heal.classification	Ιατρική
heal.classification	Ιατρική φυσική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85083001
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Ιατρική φυσική
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh94005134
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85093011
heal.contributorName	Λύρα, Μαρία	el
heal.language	en
heal.access	free
heal.publicationDate	2014
heal.bibliographicCitation	Baka, I., Ploussi, A., Argyrou, M., Valasi, A., Limouris, G.S., et al. (2014). Value of individualized dosimetry in peptide receptor radionuclide therapy (PRRT) by Lutetium-177 [177lu – Dota0, Tyr3] octreotate. "e-Journal of Science & Technology". [Online] 9(3): 43-49. Available from: http://e-jst.teiath.gr/	en
heal.abstract	Response and toxicity prediction is essential to the implementation of Peptide Receptor Radionuclide Therapy (PRRT) for neuroendocrine tumors. Radiolabelled somatostatin analogue [177Lu-DOTA0 , Tyr3 ] octreotate stands as a promising therapy tool. Specific dosimetry is a crucial factor in patient treatment planning. In our Institution, neuroendocrine tumor treatment, by radiopeptide infusion via intrahepatic arterial catheterization, is a well established technique. Kidney protective agents are also included in our protocol. The individualized patient dosimetry calculations were based on planar and SPECT scintigraphy images. Counts were determined in a region of interest (ROI) around the tumor, liver, kidneys and spleen. In planar technique, the ROIs were drawn in both anterior and posterior images while in SPECT counts measured per slice. For counts conversion to activities, calibration factors were calculated. Planar and SPECT images of cylindrical water - filled phantom, with five different known amounts of activity, were obtained. Corrections for scatter attenuation, collimator efficiency and detector response were calculated. Absorbed doses were calculated using MIRD formalism and S values were calculated using the RADAR system. The absorbed doses to organ per unity administered activity were comparable for both planar and SPECT techniques. On average, the absorbed dose was in tumor [4- 40] mGy/ MBq, in kidneys[0.25-1.05] mGy/ MBq, in the spleen [0.3-2.1] mGy/ MBq and in the liver [0.05-0.34] mGy/ MBq. In order to deliver higher dose to tumor and avoid kidneys and red marrow toxicity, accurate individualized dosimetry is obligatory. Furthermore, the results quantitatively confirm the therapeutic efficacy of transhepatic administration and introduce 177Lu labeled peptide as an ideal for peptide receptor radiotherapy.	en
heal.publisher	Νερατζής, Ηλίας	el
heal.publisher	Σιανούδης, Ιωάννης	el
heal.journalName	e-Journal of Science & Technology	en
heal.journalName	e-Περιοδικό Επιστήμης & Τεχνολογίας	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true