The crude methanol extract of the leaves of Trevesia palmata was partitioned with nhexane, ethyl acetate, chloroform and water for biological investigation. Methanol extract of Trevesia palmata was assessed for in vitro thrombolytic and anti-arthritic activity. Anti- arthritic activity was evaluated using albumin denaturation. Diclofenac sodium (D.s.) was used as a standard drug for the study of anti-inflammatory activity. The methanol extract of Trevesia palmata showed mean inhibition of protein denaturation 89.24±0.6584 at 1000µg/ml whereas, standard diclofenac sodium it was found to be 96.77±1.1404. In thrombolytic activity using in vitro clot lysis assay method, the ethyl acetate soluble fraction (LEAF) and n-hexane soluble fraction(LHXF) of leaf extract was found to have significant (p<0.001), thrombolytic activity showed a maximum effect of 44.293±0.5069 & 44.211±0.7428 while the standard streptokinase showed 71.668±0.466.