Formulation and in-vitro evaluation of oral sustained release drug delivery system for lamivudine matrix tablets using Methocel K15M CR polymer

dc.contributor.author	Rahman, Mofizur	en
dc.contributor.author	Ahsan, Qamrul	en
dc.contributor.author	Khalipha, Abul Bashar Ripon	en
dc.contributor.author	Azad, A. K.	en
dc.contributor.author	Nazneen, Ahmeda Sultana	en
dc.date.accessioned	2015-02-18T08:32:59Z
dc.date.available	2015-02-18T08:32:59Z
dc.date.issued	2015-02-18
dc.identifier.uri	http://hdl.handle.net/11400/6470
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://e-jst.teiath.gr/	en
dc.subject	Lamivudine
dc.subject	Methocel K15M CR
dc.subject	Matrix tablets
dc.subject	Sustained release
dc.subject	Λαμιβουδίνη
dc.subject	Παρατεταμένη αποδέσμευση
dc.title	Formulation and in-vitro evaluation of oral sustained release drug delivery system for lamivudine matrix tablets using Methocel K15M CR polymer	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Ιατρική
heal.classification	Pharmacy
heal.classification	Φαρμακευτική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85100603
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Φαρμακευτική
heal.contributorName	Hossain, Sophia	en
heal.contributorName	Haque, Sanjida	en
heal.language	en
heal.access	free
heal.publicationDate	2015
heal.bibliographicCitation	Rahman, M., Ahsan, Q., Khalipha, A. B. R., Azad, A. K. & Nazneen, A. S. (2015) Formulation and in-vitro evaluation of oral sustained release drug delivery system for lamivudine matrix tablets using Methocel K15M CR polymer. "e-Journal of Science & Technology". [Online] 10(1). p. 53-63. Available from: http://e-jst.teiath.gr/ [Accessed 18-02-2015]	en
heal.abstract	The present work reports the study of different proportion of Lamivudine: Methocel K15M formulations, in order to investigation the effect of polymer proportion and diluent on the drug release mechanism. Lamivudine, an anti-HIV agent, was used as a model drug to evaluate its release characteristics from different matrices. Matrix tablets of Lamivudine were prepared by direct compression process using methocel K15M CR polymer. In vitro release studies were performed using US Pharmacopeia type 1 apparatus (basket method) in 900 mL of pH 6.8 phosphate buffer at 100 rpm for 8 hours (Initial 2 hours in simulated gastric fluid (pH 1.2)). Scanning Electron Microscopy (SEM) was used to evaluate and surface properties of the matrices. Drug release was analyzed according to their kinetic models. A one-way analysis of variance (ANOVA) was used to interpret the results. Statistically significant differences were found among the drug release profile from different formulations. Higher proportion of polymeric content (25 to 30% of the total tablet weight) in the matrix, release was extended > 8 hours due to increased tortuosity and decreased porosity. At lower proportion of polymeric content (10% of the total tablet weight), the rate of drug release was elevated. Two formulations showed drug release is more controlled. The release mechanism was explored and explained with zero order, first order, Higuchi and Korsmeyer and Hixon-Crowell equations. The results generated in this study showed that the profile and kinetics of drug release were functions of polymer type, polymer level and physico-chemical properties of the drug. By suitable modulation could be developed controlled delivery of such type of drug.	en
heal.publisher	Νερατζής, Ηλίας	el
heal.publisher	Σιανούδης, Ιωάννης	el
heal.journalName	e-Journal of Science & Technology	en
heal.journalName	e-Περιοδικό Επιστήμης & Τεχνολογίας	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true