Concepts and techniques of intraoperative radiotherapy
for breast cancer

dc.contributor.author	Reitsamer, Roland	en
dc.contributor.author	Sedlmayer, Felix	en
dc.contributor.author	Kopp, Michael	en
dc.contributor.author	Kametriser, Gerhard	en
dc.contributor.author	Menzel, Christian	en
dc.date.accessioned	2015-02-23T23:09:39Z
dc.date.available	2015-02-23T23:09:39Z
dc.date.issued	2015-02-24
dc.identifier.uri	http://hdl.handle.net/11400/6819
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://link.springer.com/	en
dc.subject	Intraoperative radiotherapy
dc.subject	Breast cancer
dc.subject	Διεγχειρητική ακτινοθεραπεία
dc.subject	Καρκίνος του μαστού
dc.title	Concepts and techniques of intraoperative radiotherapy for breast cancer	en
heal.type	journalArticle
heal.classification	Pharmacology
heal.classification	Radiology, Medical
heal.classification	Φαρμακολογία
heal.classification	Ραδιοθεραπεία
heal.classificationURI	http://skos.um.es/unescothes/C02967
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85110777
heal.classificationURI	N/A-Φαρμακολογία
heal.classificationURI	N/A-Ακτινολογία, Ιατρική
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh00005893
heal.contributorName	Glueck, Silvia	en
heal.contributorName	Nairz, Olaf	en
heal.contributorName	Deutschmann, Heinz	en
heal.contributorName	Merz, Florian	en
heal.contributorName	Peintinger, Florentia	en
heal.identifier.secondary	DOI 10.1007/s12282-007-0001-4
heal.language	en
heal.access	campus
heal.recordProvider	Τ.Ε.Ι. Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ραδιολογίας και Ακτινολογίας.	el
heal.publicationDate	2008
heal.bibliographicCitation	Reitsamer, R., Sedlmayer, F., Kopp, M., Kametriser, G., Menzel, C., et al. (January 2008). Concepts and techniques of intraoperative radiotherapy for breast cancer. Breast Cancer. 15(1). pp. 40-46. Springer-Verlag: 2008. Available from: http://link.springer.com [Accessed 29/11/2007]	en
heal.abstract	The standard treatment for early breast cancer comprises wide local excision, sentinel lymph node biopsy or axillary lymph node dissection, adjuvant medical treatment and radiotherapy to the whole breast. Many studies suggest that local control plays a crucial role in overall survival. The local recurrence rate is estimated to be 1% per year and varies between 4 and 7% after 5 years and up to 10 to 20% in the long-term follow up. On the basis of low local recurrence rates the concept of whole breast irradiation comes up for discussion, and partial breast irradiation (PBI) is increasingly under consideration. Intraoperative radiotherapy (IORT) is referred to as the delivery of a single high dose of irradiation directly to the tumor bed (confined target) during surgery. PBI (limited field radiation therapy, accelerated partial breast irradiation APBI) is the irradiation exclusively confined to a breast volume, the tumor surrounding tissue (tumor bed) either during surgery or after surgery without whole breast irradiation. Various methods and techniques for IORT or PBI are under investigation. The advantage of a very short radiation time or the integration of the complete radiation treatment into the surgical procedure convinces at a first glance. The promising short-term results of those studies must not fail to mention that local recurrence rates could probably increase and furthermore give rise to distant metastases and a reduction in overall survival. The combination of IORT in boost modality and whole breast irradiation has the ability to reduce local recurrence rates. The EBCTCG overview approves that differences in local treatment that substantially affect local recurrence rates would avoid about one breast cancer death over the next 15 years for every four local recurrences avoided, and should reduce 15-year overall mortality.	en
heal.publisher	Springer-Verlag	en
heal.journalName	Breast Cancer	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true