Local recurrence rates in breast cancer patients treated with intraoperative electron-boost radiotherapy versus postoperative external-beam electron-boost irradiation

dc.contributor.author	Reitsamer, Roland	en
dc.contributor.author	Peintinger, Florentia	en
dc.contributor.author	Kopp, Michael	en
dc.contributor.author	Menzel, Christian	en
dc.contributor.author	Kogelnik, H. Dieter	en
dc.date.accessioned	2015-02-23T23:59:32Z
dc.date.available	2015-02-23T23:59:32Z
dc.date.issued	2015-02-24
dc.identifier.uri	http://hdl.handle.net/11400/6822
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://link.springer.com/	en
dc.subject	Breast cancer
dc.subject	Intraoperative radiotherapy
dc.subject	Καρκίνος μαστού
dc.subject	Διεγχειρητική ακτινοθεραπεία
dc.title	Local recurrence rates in breast cancer patients treated with intraoperative electron-boost radiotherapy versus postoperative external-beam electron-boost irradiation	en
heal.type	journalArticle
heal.secondaryTitle	a sequential intervention study	en
heal.classification	Pharmacology
heal.classification	Radiology, Medical
heal.classification	Φαρμακολογία
heal.classification	Ακτινολογία, Ιατρική
heal.classificationURI	http://skos.um.es/unescothes/C02967
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85110777
heal.classificationURI	N/A-Φαρμακολογία
heal.classificationURI	N/A-Ακτινολογία, Ιατρική
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh00005893
heal.contributorName	Sedlmayer, Felix	el
heal.identifier.secondary	DOI 10.1007/s00066-004-1190-9
heal.language	en
heal.access	campus
heal.recordProvider	Τ.Ε.Ι. Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ραδιολογίας και Ακτινολογίας.	el
heal.publicationDate	2004
heal.bibliographicCitation	Reitsamer, R., Peintinger, F., Kopp, M., Menzel, C., Kogelnik, D., et al. (January 2004). Local recurrence rates in breast cancer patients treated with intraoperative electron-boost radiotherapy versus postoperative external-beam electron-boost irradiation: a sequential intervention study. Strahlentherapie und Onkologie. 180(1). pp. 38-44. Springer-Verlag: 2004. Available from: http://link.springer.com/	en
heal.abstract	Background and Purpose: The purpose of this sequential intervention study was to determine the rate of local recurrences and the rate of distant metastases in patients with invasive breast cancer who had been treated with breast-conserving surgery and postoperative radiation therapy to the whole breast either with postoperative electron boost in group 1 or with intraoperative electron boost (IORT) in group 2. Patients and Methods: After breast-conserving surgery, 378 women with invasive breast cancer of tumor sizes T1 and T2 received 51–56.1 Gy of postoperative radiation therapy to the whole breast in 1.7-Gy fractions. 188 of those patients additionally received a postoperative electron boost of 12 Gy in group 1 from January 1996 to October 1998. Consecutively, from October 1998 to March 2001, 190 patients received intraoperative electron-boost radiotherapy of 9 Gy to the tumor bed in group 2. The groups were comparable with regard to age, menopausal status, tumor size, grading, and nodal status. All statistical tests were twosided. Results: During a median follow-up period of 55.3 months in group 1 and 25.8 months in group 2, local recurrences were observed in eight of 188 patients (4.3%) in group 1, and no local recurrence was seen in group 2 (p = 0.082). Distant metastases occurred in 15 of the 188 patients (7.9%) in group 1 and in two of the 190 patients (1.1%) in group 2 (p = 0.09). The 4-year actuarial rates of local recurrence were 4.3% (95% confidence interval, 1.8–8.2%) and 0.0% (95% confidence interval, 0.0–1.9%) and the 4-year actuarial rates of distant metastases were 7.9% (95% confidence interval, 4.5–12.8%) and 1.1% (95% confidence interval, 0.1–3.8%). Conclusion: Immediate IORT boost yielded excellent local control figures in this prospective investigation and appears to be superior to conventional postoperative boost in a short-term follow-up.	en
heal.publisher	Springer-Verlag	en
heal.journalName	Strahlentherapie und Onkologie	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true