Intraoperative radiotherapy given as a boost after breast-conserving
surgery in breast cancer patients

dc.contributor.author	Reitsamera, R.	el
dc.contributor.author	Peintingerb, F.	el
dc.contributor.author	Sedlmayerc, F.	el
dc.contributor.author	Kopp, Michael	el
dc.contributor.author	Menzel, C.	el
dc.date.accessioned	2015-02-24T00:19:51Z
dc.date.available	2015-02-24T00:19:51Z
dc.date.issued	2015-02-24
dc.identifier.uri	http://hdl.handle.net/11400/6823
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.sciencedirect.com/	en
dc.subject	Breast cancer
dc.subject	Intraoperative radiotherapy
dc.subject	Καρκίνος του μαστού
dc.subject	Διεγχειρητική ακτινοθεραπεία
dc.title	Intraoperative radiotherapy given as a boost after breast-conserving surgery in breast cancer patients	en
heal.type	journalArticle
heal.classification	Pharmacology
heal.classification	Radiology, Medical
heal.classification	Φαρμακολογία
heal.classification	Ακτινολογία, Ιατρική
heal.classificationURI	http://skos.um.es/unescothes/C02967
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85110777
heal.classificationURI	N/A-Φαρμακολογία
heal.classificationURI	N/A-Ακτινολογία, Ιατρική
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh00005893
heal.contributorName	Cimpocaa, W.	el
heal.contributorName	Glueck, S.	el
heal.contributorName	Rahimc, H.	el
heal.contributorName	Kopp, P.	el
heal.contributorName	Deutschmann, H.	el
heal.contributorName	Merz, F.	el
heal.contributorName	Brandis, M.	el
heal.contributorName	Kogelnik, H.	el
heal.identifier.secondary	doi:10.1016/S0959-8049(02)00116-8
heal.language	en
heal.access	campus
heal.recordProvider	Τ.Ε.Ι. Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ραδιολογίας και Ακτινολογίας.	el
heal.publicationDate	2002
heal.bibliographicCitation	Reitsamer, R., Peintinger, F., Sedlmayerc, F., Kopp, M., Menzel, C., et al. (August 2002). Intraoperative radiotherapy given as a boost after breast-conserving surgery in breast cancer patients. European Journal of Cancer. 38(12). pp. 1607–1610. Elsevier Science Ltd: 2002. Available from: http://www.sciencedirect.com [Accessed 16/04/2002]	en
heal.abstract	Conventional radiotherapy after breast-conserving therapy is confined to 50–55 Gy external beam radiation therapy (EBRT) to the whole breast and 10–16 Gy external boost radiation to the tumour bed or brachytherapy to the tumour bed. Local recurrence rate after breast-conserving surgery varies between 5 and 18%. External boost radiation can partially miss the tumour bed and therefore can result in local failure. Intra-operative radiotherapy (IORT) as a high precision boost can prevent a ‘geographical miss’. From October 1998 to December 2000, 156 patients with stage I and stage II breast cancer were operated upon in a dedicated IORT facility. After local excision of the tumour, the tumour bed was temporarily approximated by sutures to bring the tissue in the radiation planning target volume. A single dose of 9 Gy was applied to the 90% reference isodose with energies ranging from 4 to 15 MeV, using round applicator tubes 4–8 cm in diameter. After wound healing, the patients received additional 51–56 Gy EBRT to the whole breast. No acute complications associated with IORT were observed. In 5 patients, a secondary mastectomy had to be performed because of tumour multicentricity in the final pathological report or excessive intraductal component. 2 patients developed rib necroses. In 7 patients, wound healing problems occurred. After a mean follow-up of 18 months, no local recurrences were observed. Cosmesis of the breast was very good and comparable to patients without IORT. Preliminary data suggest that IORT given as a boost after breast-conserving surgery could be a reliable alternative to conventional postoperative fractionated boost radiation by accurate dose delivery and avoiding geographical misses, by enabling smaller treatment volumes and complete skin-sparing and by reducing postoperative radiation time by 7–14 days.	en
heal.publisher	Elsevier Science Ltd	en
heal.journalName	European Journal of Cancer	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true