Maximizing the benefits of screening mammography for women 40-49 years old

dc.contributor.author	Μπασταρδής-Ζάκας, Κ.	el
dc.contributor.author	Ιατράκης, Γεώργιος Μ.	el
dc.contributor.author	Ναυρόζογλου, Ιορδάνης	el
dc.contributor.author	Πεϊτσίδης, Παναγιώτης	el
dc.contributor.author	Σαλάκος, Νικόλαος	el
dc.date.accessioned	2015-02-26T09:17:56Z
dc.date.issued	2015-02-26
dc.identifier.uri	http://hdl.handle.net/11400/6943
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.ncbi.nlm.nih.gov/pubmed/21355457	el
dc.subject	Mammography before 50 years old
dc.subject	Screening mammography
dc.subject	Mammography in young women
dc.subject	Μαστογραφία πριν τα 50 έτη
dc.subject	Μαστογραφία προσυμπτωματικού ελέγχου
dc.subject	Μαστογραφία σε νεαρές γυναίκες
dc.title	Maximizing the benefits of screening mammography for women 40-49 years old	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Midwifery
heal.classification	Ιατρική
heal.classification	Μαιευτική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh96006072
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Μαιευτική
heal.contributorName	Μαλακάσσης, Πέτρος	el
heal.contributorName	Ζερβούδης, Στέφανος	el
heal.identifier.secondary	ISSN:0390-6663
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	forever
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας.Σχολή Επαγγελμάτων Υγείας και Πρόνοιας.Τμήμα Μαιευτικής	el
heal.publicationDate	2010
heal.bibliographicCitation	Bastardis-Zakas, K., Iatrakis, G., Navrozoglou, I., Peitsidis, P., Salakos, N., et.al.(2010).Maximizing the benefits of screening mammography for women 40-49 years old.Clinical and Experimental Obstetrics Gynecology 37(4).pp 278-282.Canada: I.R.O.G.	el
heal.abstract	BACKGROUND: While women aged 50 and older are broadly considered to benefit from screening mammograms, the evidence of any similar advantages for younger women are still considered insufficient to form any substantial conclusions on the matter. The primary goal of this study was to examine whether or not the mortality rate of younger women is benefited by mammography, and if so, how can this beneficial effect be maximized. METHODS: The authors have taken into account all available randomized control trials (RCTs) and have conducted a meta-analysis based on those RCTs to study the effect of mammography on the mortality rate of women younger than age 50. Further interpretation on various aspects of the results has also led to separate meta-analyses, with the RCTs included grouped in accordance to the mean time interval between screening mammograms employed by each study. The findings and conclusions of the comparison were used to calculate the number of mammograms necessary to reduce the absolute death risk, depending on the time interval between screening mammograms. RESULTS: The meta-analysis indicated a reduction in breast-cancer mortality in the intervention group, which reached statistical significance (relative risk (RR) 0.81 [95% CI 0.71-0.93] p < 0.01). Furthermore, when the RCTs included were grouped according to their mean time interval between mammograms, there was a definite increase of statistical significance in favor of those RCTs with shorter interval times (RR 0.76 [95% CI 0.64-0.89] p < 0.01). CONCLUSIONS: The significant mortality rate reduction demonstrated by the meta-analytical results is a key indicator of the beneficial effect of mammography on the age group of women younger than 50. Additionally, the increase in the aforesaid significance when combining RCTs with short time intervals between mammograms, as opposed to those RCTs with longer intervals, suggests that the optimal use of mammographic screening lies with the former. This is better demonstrated when taking in account our approach to answering the practical question of "how many screening mammograms will take to save one life?" in correlation with the mean time interval involved.	en
heal.publisher	I.R.O.G.	en
heal.journalName	Clinical and Experimental Obstetrics Gynecology	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true