Determination of CD4+ and CD8+ T cells in the peripheral blood of dogs with leishmaniosis before and after prolonged allopurinol monotherapy

dc.contributor.author	Παπαδογιαννάκης, Εμμανουήλ Ι.	el
dc.contributor.author	Ανδρίτσος, Γεώργιος Δ.	el
dc.contributor.author	Κοντός, Βασίλειος Ι.	el
dc.contributor.author	Σπανάκος, Γρηγόρης	el
dc.contributor.author	Κουτής, Χαρίλαος	el
dc.date.accessioned	2015-04-17T10:44:14Z
dc.date.issued	2015-04-17
dc.identifier.uri	http://hdl.handle.net/11400/8469
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.journals.elsevier.com/the-veterinary-journal/
dc.source	http://www.sciencedirect.com
dc.subject	Ανοσοποιητικό σύστημα
dc.subject	Σκύλοι Ασθένειες
dc.subject	Immune system
dc.subject	Dogs--Diseases
dc.title	Determination of CD4+ and CD8+ T cells in the peripheral blood of dogs with leishmaniosis before and after prolonged allopurinol monotherapy	en
heal.type	journalArticle
heal.classification	Public health
heal.classification	Veterinary medicine
heal.classification	Δημόσια υγεία
heal.classification	Κτηνιατρική
heal.classificationURI	http://lod.nal.usda.gov/28292
heal.classificationURI	http://lod.nal.usda.gov/9135
heal.classificationURI	N/A-Δημόσια υγεία
heal.classificationURI	N/A-Κτηνιατρική
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh86006453
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85038798
heal.contributorName	Βελονάκης, Εμμανουήλ Γ.	el
heal.identifier.secondary	10.1016/j.tvjl.2009.08.001
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	campus
heal.publicationDate	2009-09-03
heal.bibliographicCitation	Papadogiannakis, E., Andritsos, G., Kontos, V., Spanakos, G. and Koutis, C. (2009). Velonakis E. Determination of CD4+ and CD8+ T cells in the peripheral blood of dogs with leishmaniosis before and after prolonged allopurinol monotherapy. "The Veterinary Journal".[Online] 186 (2): p.262-3. Available from: http://www.sciencedirect.com [Accessed 17/04/2015]	en
heal.abstract	Canine leishmaniosis (CL) is a common systemic parasitic disease that is endemic in many Mediterranean countries including Greece. The immune reaction to the parasite is critical to the outcome of the infection and the response to treatment. Some studies have shown a reduction of circulating CD4+ T cells and of the CD4+/CD8+ ratio in dogs with CL and these changes normalised following treatment with meglumine antimoniate or amphotericin B. Allopurinol is used as a monotherapy for the chronic treatment of CL. The aim of the present study was to determine the circulating CD4+ and CD8+ T lymphocyte numbers and the CD4+/CD8+ ratio in 19 dogs diagnosed with CL before and after prolonged allopurinol monotherapy (18 months). A significant decrease in circulating CD4+ T cells was observed in dogs with CL before treatment. Prolonged allopurinol monotherapy improved the number of circulating CD4+ T cells, but did not restore their number to within the normal range.	en
heal.journalName	The Veterinary Journal	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true