Cumulative keyboard strokes

dc.contributor.author	Ελευθερίου, Ανδρέας	el
dc.contributor.author	Ραχιότης, Γιώργος	el
dc.contributor.author	Βαρυτιμίδης, Σωκράτης Ε.	el
dc.contributor.author	Κουτής, Χαρίλαος	el
dc.contributor.author	Μαλίζος, Κωνσταντίνος Ν.	el
dc.date.accessioned	2015-04-18T01:31:39Z
dc.date.issued	2015-04-18
dc.identifier.uri	http://hdl.handle.net/11400/8505
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.occup-med.com	en
dc.subject	πολυμορφισμός
dc.subject	Greece
dc.subject	Ελλάδα
dc.subject	ενώσεις
dc.subject	associations
dc.subject	polymorphisms
dc.title	Cumulative keyboard strokes	en
heal.type	journalArticle
heal.secondaryTitle	a possible risk factor for carpal tunnel syndrome	en
heal.classification	Ιατρική
heal.classification	Παθολογία
heal.classification	Medicine
heal.classification	Pathology
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Παθολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://skos.um.es/unescothes/C02921
heal.keywordURI	http://zbw.eu/stw/descriptor/17184-0
heal.contributorName	Χατζηχριστοδούλου, Χρήστος	el
heal.identifier.secondary	10.1186/1745-6673-7-16
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	free
heal.publicationDate	2011-10
heal.bibliographicCitation	Eleftheriou, A., Rachiotis, G., Varitimidis, S., Koutis, Ch., Malizos, K.N., et al. (2012). Cumulative keyboard strokes: A possible risk factor for carpal tunnel syndrome. "Journal of Occupational Medicine and Toxicology".[Online] 7:16. Available from: http://www.occup-med.com [Accessed 17/04/2015]	en
heal.abstract	Paraoxonases and cytochromes P450 constitute two major classes of xenobiotic-metabolizing enzymes involved in the detoxification of pesticide chemicals. In this study, we examined the distribution of two common genetic polymorphisms of the paraoxonase 1 gene and one common polymorphism of the CYP1A1 gene, in relation to pathological diseases occurring in a rural population. Blood and hair samples were collected from 220 participants of an agricultural cohort in the south of Greece for genotype and pesticide analysis. Demographic information and disease status of the participants was obtained by questionnaire, medical examination and medical record. Organochlorine pesticides and metabolites (DDTs, HCHs) were extracted from hair and analyzed using gas chromatography combined with mass spectrometry techniques. Our results indicate exposure of the rural population of Amaliada to organophosphate and past exposure to organochlorine pesticides. Genotypic analysis of PON1Q192R, PON1L55M and CYP1A1*2A MspI polymorphisms was performed using PCR-RFLP. The PON1 192R and 55M alleles absence was significantly associated with hypertension (OR: 2.59; 95% CI: 1.10–6.09) and hepatitis (OR: 21.43; 95% CI: 2.53–181.50), respectively, as indicated from backward logistic regression. Although the presence of PON1 192R allele significantly affected the occurrence of prostate hyperplasia (OR: 0.35; 95% CI: 0.03–0.40), no associations were obtained between the paraoxonase serum activity or the CYP1A1 genotype and the disease status.	en
heal.journalName	Journal of Occupational Medicine and Toxicology	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true