Introduction: The last decades exists an increase of infections in children patients with cancer mainly because resistant to antibiotics pathogenic organisms. The confrontation of problem is reduced in strategies of control of infections that propose good hygiene via basic and intensive precautions. Aim: To present the modern dimensions of this problem through systematic examination of bibliography. Method:Systematic review of the literature of the electronic databases (Medline/Pudmed, Cinahl, Scopus, HEAL Link) & critical analysis of the relevant articles that were retrieved for the years 1996–2011. The initial number of the retrieved articles was 5.988 from which 15 fulfilled the eligibility criteria: (i) the studies were written in English language and published in peer reviewed journals, (ii) the sample of the studies consisted of children in-patients, and (iii) the studies had explicit methodology and results. A scale for quality estimation of was used in order to evaluate the quality of studies. Results: Twenty percent of the studies were not-randomized studies with control group and rated ‡60%. The results of these studies show an important reduction or elimination of VRE with the implementation of bundled nursing interventions. Behavioral interventions described in these studies included education and the use of a multidisciplinary team. 66.7% of the studies were applied five nursing interventions for the reduction of colonization of VRE, while in the 33.3%>5. The 80% of studies concerned not-randomized in which became simultaneous implementation of all interventions for the reduction of colonization of VRE with only after measurements. 41.6% of these report elimination of VRE, the 41.6% important reduction and the 16.8% reduction. Conclusions: There is strong evidence about the use of bundled nursing interventions for the reduction of colonization of VRE in children in-patient but is strongly recommended to test further the application of these interventions with the use of powerful methodology