New nystatin polymeric complexes and their in vitro antifungal evaluation in a model study with fusarium oxysporum

dc.contributor.author	Χαρβάλου, Αικατερίνη	el
dc.contributor.author	Λιάπη, Χ.	el
dc.contributor.author	Τσατσάκης, Αριστείδης Μ.	el
dc.contributor.author	Τζατζαράκης, Μανώλης Ν.	el
dc.contributor.author	Γαλανοπούλου, Π.	el
dc.date.accessioned	2015-04-19T15:21:58Z
dc.date.available	2015-04-19T15:21:58Z
dc.date.issued	2015-04-19
dc.identifier.uri	http://hdl.handle.net/11400/8564
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	www.researchgate.net	en
dc.subject	Nystatin
dc.subject	Νυστατίνη
dc.title	New nystatin polymeric complexes and their in vitro antifungal evaluation in a model study with fusarium oxysporum	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Public health
heal.classification	Ιατρική
heal.classification	Δημόσια υγεία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://lod.nal.usda.gov/28292
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Δημόσια υγεία
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85089200
heal.contributorName	Κουτής, Χαρίλαος	el
heal.identifier.secondary	10.1023/A:1015252121285
heal.language	en
heal.access	free
heal.publicationDate	2002
heal.bibliographicCitation	Charvalos, E., Liapi, C., Tsatsakis, A., Tzatzarakis, M., Galanopoulou, P., et al (2002). New nystatin polymeric complexes and their in vitro antifungal evaluation in a model study with Fusarium oxysporum. "Pharmacologist". [Online]. 4(2): p.1. Available from: http://www.researchgate.net [Accessed 19/04/2015]	el
heal.abstract	Six water-soluble nystatin-polyvilnylpyrrolidone complexes with respective MW of 10 kDa (NC1), 25 kDa (NC2), 30 kDa (NC3), 40 kda (NC4), 90 kDa (NC5), 360 kDa (NC6) were synthesized. The activity of the complexes was compared with that of nystatin against growth and spore germination of Fusarium oxysporum f.sp. radiciscucumerinum. The ED50 value (effective dose) of free nystatin in aqueous solution on growth inhibition on solid medium was determined at 35.7 ppm. The ED50 of the complexes NC3, NC4, NC5, and NC6 ranged from 2.2 to 4 times lower than that of nystatin. The NC6 complex exhibited the highest activity, followed by NC5, NC4, and NC3. The activities of NC1 and NC2 were about 3 and 1.7 times higher than nystatin respectively in the same in vitro model. The complexes NC6. NC1 and NC4 were 25.4, 13.6 and 6.9 times more active respectively than nystatin against spore germination of E oxysporum. The activity of the nystatin complexes was dependent on the molecular weight of the polymeric carrier. New nystatin polymeric complexes and their in vitro antifungal evaluation in a model study with Fusarium oxysporum. The activity of the nystatin complexes was dependent on the molecular weight of the polymeric carrier.	en
heal.journalName	Pharmacologist	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true