Analysis of pon1 polymorphisms on a rural greek population of Peloponnesus

dc.contributor.author	Ζαφειρόπουλος, Αλξέξανδρος	el
dc.contributor.author	Κωνσταντίνου, Παναγιώτα	el
dc.contributor.author	Κουτής, Χαρίλαος	el
dc.contributor.author	Μπαμπάτσικου, Φωτούλα Π.	el
dc.contributor.author	Καφάτος, Αντώνης Γ.	el
dc.date.accessioned	2015-04-21T15:48:55Z
dc.date.issued	2015-04-21
dc.identifier.uri	http://hdl.handle.net/11400/8615
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.researchgate.net	en
dc.subject	Επιστημονική έρευνα
dc.subject	Άτομο
dc.subject	Scientific Research
dc.subject	Atom
dc.title	Analysis of pon1 polymorphisms on a rural greek population of Peloponnesus	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Public health
heal.classification	Ιατρική
heal.classification	Δημόσια υγεία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://lod.nal.usda.gov/28292
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Δημόσια υγεία
heal.contributorName	Τζανακάκης, Γ.	el
heal.contributorName	Τσατσάκης, Αριστείδης Μ.	el
heal.identifier.secondary	10.1016/j.toxlet.2007.05.448
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	forever
heal.publicationDate	2007
heal.bibliographicCitation	Zafiropoulos, A., Konstantinou, P., Koutis, Ch., Babatsikou, F., Kafatos, A., et. al. (2007). Analysis of PON1 polymorphisms on a rural Greek population of Peloponnesus. "Toxicology Letters". [Online] 172: p.176. Available from: http://www.researchgate.net [Accessed 20/04/2015]	en
heal.tableOfContents	Specific polymorphisms of the paraoxonase 1 gene have been shown to influence greatly the ability of the produced enzyme to metabolize xenobiotic substances. These significant variations in the paraoxonase activity could be responsible for the variable sensitivity of different individuals to organophosphate compounds. The objective of our study was to investigate the distribution of the PON1 Q192R and the L55M polymorphisms in a rural Greek population exposed due to profession to a variety of toxic organophosphates and examine its impact in the incidence of various clinicopathological conditions. Our study focused on an isolated rural population from Amaliada Peloponnesus. We collected an aliquot of peripheral blood as well as relevant personal and medical history data by interviewing 139 individuals. Genomic DNA was extracted and the genotype regarding the polymorphisms was determined by PCR RFLP. We observed 61.8% PON1 QQ homozygote-, 33.8% QR heterozygote and 4.4% RR homozygote-carrying individuals. We also observed 40.4% PON1 LL homozygote-, 44.1% LM heterozygote and 15.5% MM homozygote-carrying individuals. The rare PON1 R and M allele frequencies were 0.21 and 0.37 respectively. All genotype frequencies appeared in Hardy–Weinberg equilibrium. Statistical analysis of the genotypes with the personal and medical history of the individuals revealed a significant positive correlation between the PON1 R allele and prostate hypertrophy (p = 0.004). PON1 R and L alleles correlated with stillbirths/births with genetic abnormalities (p = 0.002 and p = 0.006, respectively). Our results show a potential involvement of specific mutant alleles in different disease and birth outcomes. This report is a part of our ongoing population and environmental study of exposure to pesticides and assessment of its effect on public health.	el
heal.journalName	Toxicology Letters	el
heal.journalType	peer-reviewed
heal.fullTextAvailability	true