Multiple ADH genes are associated with upper aerodigestive cancers

dc.contributor.author	Hashibe, Mia	en
dc.contributor.author	McKay, James, D.	en
dc.contributor.author	Curado, Maria Paula	en
dc.contributor.author	Oliveira, Jose Carlos	en
dc.contributor.author	Koifman, Sergio	en
dc.date.accessioned	2015-04-21T16:01:52Z
dc.date.issued	2015-04-21
dc.identifier.uri	http://hdl.handle.net/11400/8616
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.nature.com/	en
dc.subject	Oncology
dc.subject	Cancer
dc.subject	Ογκολογία
dc.subject	Καρκίνος
dc.title	Multiple ADH genes are associated with upper aerodigestive cancers	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Biology
heal.classification	Ιατρική
heal.classification	Βιολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://zbw.eu/stw/descriptor/15633-0
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Βιολογία
heal.keywordURI	http://skos.um.es/unesco6/320713
heal.contributorName	Koifman, Rosalina	en
heal.contributorName	Zaridze, David	en
heal.contributorName	Shangina, Oxana	en
heal.contributorName	Wunsch-Filho, Victor	en
heal.contributorName	Eluf-Neto, Jose	en
heal.contributorName	Levi, Jose Eduardo	en
heal.contributorName	Matos, Elena	en
heal.contributorName	Λάγιου, Παγώνα, Δ. (1967-)	el
heal.contributorName	Λάγιου, Αρετή	el
heal.contributorName	Benhamou, Simone	en
heal.contributorName	Bouchardy, Christine	en
heal.contributorName	Szeszenia-Dabrowska, Neonilia	en
heal.contributorName	Menezes, Ana	en
heal.contributorName	Dall'Agnol, Marinel Mor	en
heal.contributorName	Merletti, Franco	en
heal.contributorName	Richiardi, Lorenzo	en
heal.contributorName	Fernandez, Leticia	en
heal.contributorName	Lence, Juan	en
heal.contributorName	Talamini, Renato	en
heal.contributorName	Barzan, Luigi	en
heal.contributorName	Mates, Dana	en
heal.contributorName	Mates, Ioan Nicolae	en
heal.contributorName	Kjaerheim, Kristina	en
heal.contributorName	Macfarlane, Gary John	en
heal.contributorName	Victorovna Macfarlane, Tatiana	en
heal.contributorName	Simonato, Lorenzo	en
heal.contributorName	Canova, Cristina	en
heal.contributorName	Holcatova, Ivana	en
heal.contributorName	Agudo, Antonio	en
heal.contributorName	Castellsague, Xavier	en
heal.contributorName	Lowry, Ray	en
heal.contributorName	Janout, Vladimir	en
heal.contributorName	Kollarova, Helena	en
heal.contributorName	Conway, David Ian	en
heal.contributorName	McKinney, Patricia Ann	en
heal.contributorName	Znaor, Ariana	en
heal.contributorName	Fabianova, Eleonora	en
heal.contributorName	Bencko, Vladimir	en
heal.contributorName	Lissowska, Jolanta	en
heal.contributorName	Chabrier, Amelie	en
heal.contributorName	Hung, Rayjean, J.	en
heal.contributorName	Gaborieau, Valerie	en
heal.contributorName	Boffetta, Paolo	en
heal.contributorName	Brennan, Paul	en
heal.identifier.secondary	DOI: 10.1038/ng.151
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	forever
heal.recordProvider	Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Δημόσιας Υγείας και Κοινοτικής Υγείας. Κατεύθυνση Δημόσιας Υγείας (Δημόσιας Υγιεινής)	en
heal.publicationDate	2008-05-25
heal.bibliographicCitation	Hashibe, M., McKay, J., Curado, M.P., Oliveira, J.C., Koifman, S., et al. (2008) Multiple ADH genes are associated with upper aerodigestive cancers. "Nature Genetics", 40 (6), p. 707-709. Available from: http://www.nature.com/ng/journal/v40/n6/full/ng.151.html [Accessed: 21/04/2015]	en
heal.abstract	Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10−10 and 10−9, respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology.	en
heal.journalName	Nature Genetics	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	false