Levels and correlates of alpha-fetoprotein in normal pregnancies among Caucasian and Chinese women

dc.contributor.author	Λάγιου, Παγώνα, Δ. (1967-)	el
dc.contributor.author	Σαμόλη, Ευαγγελία	el
dc.contributor.author	Λάγιου, Αρετή	el
dc.contributor.author	Lambe, Mats	en
dc.contributor.author	Τριχόπουλος, Δημήτρης Βασ. (1938-2014)	el
dc.date.accessioned	2015-04-21T16:51:22Z
dc.date.issued	2015-04-21
dc.identifier.uri	http://hdl.handle.net/11400/8621
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://journals.lww.com/	en
dc.subject	Oncology
dc.subject	Cancer
dc.subject	Ογκολογία
dc.subject	Καρκίνος
dc.title	Levels and correlates of alpha-fetoprotein in normal pregnancies among Caucasian and Chinese women	en
heal.type	journalArticle
heal.classification	Biology
heal.classification	Pregnancy
heal.classification	Βιολογία
heal.classification	Εγκυμοσύνη
heal.classificationURI	http://zbw.eu/stw/descriptor/15633-0
heal.classificationURI	http://skos.um.es/unescothes/C03111
heal.classificationURI	N/A-Βιολογία
heal.classificationURI	N/A-Εγκυμοσύνη
heal.keywordURI	http://skos.um.es/unesco6/320713
heal.contributorName	Adami, Hans Olov	en
heal.contributorName	Hsieh, Chung Cheng	en
heal.identifier.secondary	DOI: 10.1097/01.cej.0000228414.00634.53
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	forever
heal.recordProvider	Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Δημόσιας Υγείας και Κοινοτικής Υγείας. Κατεύθυνση Δημόσιας Υγείας (Δημόσιας Υγιεινής)	el
heal.publicationDate	2007-06
heal.bibliographicCitation	Lagiou, P., Samoli, E., Lagiou, A., Lambe, M., Trichopoulos, D., et al. (2007) Levels and correlates of alpha-fetoprotein in normal pregnancies among Caucasian and Chinese women. "European Journal of Cancer Prevention", 16 (3), p. 178-183. Available from: http://journals.lww.com/eurjcancerprev/Abstract/2007/06000/Levels_and_correlates_of_alpha_fetoprotein_in.3.aspx [Accessed: 21/04/2015]	en
heal.abstract	Alpha-fetoprotein has been suggested to have anti breast cancer properties both in adult life and in utero. We studied correlates of maternal serum α-fetoprotein levels in normal singleton pregnancies. This was a prospective study relying on women attending maternal units in major teaching hospitals in Boston, USA and Shanghai, China. Specifically, 212 Caucasian women in Boston, and 196 Asian women in Shanghai provided blood samples at the 16th and 27th gestational week. Maternal serum α-fetoprotein levels were measured and correlated with maternal and newborn parameters through multiple regression procedures, controlling for a set of potential confounders, including maternal levels of measured hormones. Alpha-fetoprotein was strongly inversely associated with maternal prepregnancy body mass index (−4.73 ng/l at the 27th week per 1 kg/m2 of body mass index, with 95% confidence intervals −7.09 to −2.36), whereas it was not related to parity, gender of offspring or birth weight. Duration of gestation was inversely associated with maternal α-fetoprotein levels, particularly among Caucasian women (−0.22 weeks per 60 ng/l of α-fetoprotein at the 27th week, with 95% confidence intervals −0.39 to −0.05). In normal pregnancies, maternal α-fetoprotein is inversely related to prepregnancy body mass index and appears to have a physiologic role on duration of gestation rather than on birth weight.	en
heal.journalName	European Journal of Cancer Prevention	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	false