Comparison of age at first full-term pregnancy between women with breast cancer and women with benign breast diseases

dc.contributor.author	Λάγιου, Αρετή	el
dc.contributor.author	Λάγιου, Παγώνα, Δ. (1967-)	el
dc.contributor.author	Βασιλάρου, Ντόροθυ Σταματία	el
dc.contributor.author	Στοϊκίδου, Μελπομένη	el
dc.contributor.author	Τριχόπουλος, Δημήτρης Βασ. (1938-2014)	el
dc.date.accessioned	2015-04-22T15:06:16Z
dc.date.available	2015-04-22T15:06:16Z
dc.date.issued	2015-04-22
dc.identifier.uri	http://hdl.handle.net/11400/8691
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291097-0215	en
dc.subject	Age at first pregnancy
dc.subject	Breast cancer
dc.subject	Benign breast disease
dc.subject	Ηλικία στην πρώτη εγκυμοσύνη	el
dc.subject	Καρκίνος του μαστού	el
dc.subject	Καλοήθης νόσος μαστού	el
dc.title	Comparison of age at first full-term pregnancy between women with breast cancer and women with benign breast diseases	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Oncology
heal.classification	Ιατρική
heal.classification	Ογκολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85094724
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Ογκολογία
heal.identifier.secondary	DOI: 10.1002/ijc.11476
heal.language	en
heal.access	free
heal.recordProvider	Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Δημόσιας Υγείας και Κοινοτικής Υγείας. Κατεύθυνση Δημόσιας Υγείας (Δημόσιας Υγιεινής)	el
heal.publicationDate	2003-12-10
heal.bibliographicCitation	Lagiou, A., Lagiou, P., Vassilarou, D. S., Stoikidou, M. and Trichopoulos, D. (2003) Comparison of age at first full-term pregnancy between women with breast cancer and women with benign breast diseases. "International Journal of Cancer", 107 (5), p. 817-821. Available from: http://onlinelibrary.wiley.com/doi/10.1002/ijc.11476/full [Accessed: 22/04/2015]	en
heal.abstract	Benign breast diseases have a broadly similar risk profile to that of breast cancer, possibly reflecting a similar underlying endocrine milieu. We have hypothesized that a crucial distinction between breast cancer and benign breast diseases is that mammary gland terminal differentiation has not been successfully accomplished among women who tend to de- velop breast cancer. From October 2001 to December 2002, information concerning breast cancer risk factors and socio- demographic characteristics was collected from 174 women with breast cancer and 116 women with benign breast dis- eases, all 30 years old or older, who were histologically diagnosed at a major prevention center in Athens, Greece. Among the examined breast cancer risk factors, only age at first full-term pregnancy was significantly associated with the odds of having breast cancer rather than benign breast disease, and the association was evident among premenopausal [odds ratio (OR) per 5 years = 1.76, 95% confidence interval (CI) 1.10–2.93] and postmenopausal (OR = 2.10, 95% CI 1.16–3.71) women, as well as among all women (OR = 1.93, 95% CI 1.34–2.70). There was no evidence that any of the remaining breast cancer risk factors could discriminate between breast cancer and benign breast diseases. We con- clude that early age at first pregnancy may convey substantial protection against breast cancer risk among women with benign breast diseases, probably operating through induction of terminal differentiation of mammary gland cells. The find- ing is accentuated by the fact that women with benign breast diseases are already at a relatively high risk for breast cancer.	en
heal.journalName	International Journal of Cancer	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true