Transient and cumulative memory impairments induced by GSM 1.8 GHz cell phone signal in a mouse model

dc.contributor.author	Σκουρολιάκου, Αικατερίνη	el
dc.contributor.author	Nτζούνη, Μαρία	el
dc.contributor.author	Κωστομητσόπουλος, Νικόλαος	el
dc.contributor.author	Μαργαρίτης, Λουκάς Χ.	el
dc.date.accessioned	2015-04-23T18:52:50Z
dc.date.issued	2015-04-23
dc.identifier.uri	http://hdl.handle.net/11400/8795
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.ncbi.nlm.nih.gov/pubmed/23320614	en
dc.subject	ηλεκτρομαγνητικά πεδία
dc.subject	κινητό τηλέφωνο
dc.subject	έργο εντοπισμού αντικειμένων
dc.subject	αποστολή αναγνώρισης αντικειμένων
dc.subject	μνήμη αναγνώρισης
dc.subject	χωρική μνήμη
dc.subject	Electromagnetic fields
dc.subject	Mobile phones
dc.subject	object location task
dc.subject	object recognition task
dc.subject	recognition memory
dc.subject	spatial memory
dc.title	Transient and cumulative memory impairments induced by GSM 1.8 GHz cell phone signal in a mouse model	en
heal.type	journalArticle
heal.classification	Βιοφυσική
heal.classification	Μοριακή βιολογία
heal.classification	Biophysics
heal.classification	Cell biology
heal.classificationURI	N/A-Βιοφυσική
heal.classificationURI	N/A-Μοριακή βιολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85014253
heal.classificationURI	http://skos.um.es/unescothes/C00536
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85042168
heal.keywordURI	http://skos.um.es/unescothes/C02557
heal.identifier.secondary	DOI: 10.3109/15368378.2012.709207
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	forever
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Τεχνολογικών Εφαρμογών. Τμήμα Μηχανικών Ενεργειακής Τεχνολογίας Τ.Ε	el
heal.publicationDate	2013-03
heal.bibliographicCitation	Ntzouni, M.P., Skouroliakou, A., Kostomitsopoulos, N. and Margaritis, L.H. (2013) Transient and cumulative memory impairments induced by GSM 1.8 GHz cell phone signal in a mouse model. Electromagnetic Biology and Medicine. [Online] 32 (1), pp.95-120. Available from: http://www.ncbi.nlm.nih.gov [Accessed 23/04/2015]	en
heal.abstract	This study was designed to investigate the transient and cumulative impairments in spatial and non-spatial memory of C57Bl/6J mice exposed to GSM 1.8 GHz signal for 90 min daily by a typical cellular (mobile) phone at a specific absorption rate value of 0.11 W/kg. Free-moving male mice 2 months old were irradiated in two experimental protocols, lasting for 66 and for 148 days respectively. Each protocol used three groups of animals (n = 8 each for exposed, sham exposed and controls) in combination with two behavioural paradigms, the object recognition task and the object location task sequentially applied at different time points. One-way analysis of variance revealed statistically significant impairments of both types of memory gradually accumulating, with more pronounced effects on the spatial memory. The impairments persisted even 2 weeks after interruption of the 8 weeks daily exposure, whereas the memory of mice as detected by both tasks showed a full recovery approximately 1 month later. Intermittent every other day exposure for 1 month had no effect on both types of memory. The data suggest that visual information processing mechanisms in hippocampus, perirhinal and entorhinal cortex are gradually malfunctioning upon long-term daily exposure, a phenotype that persists for at least 2 weeks after interruption of radiation, returning to normal memory performance levels 4 weeks later. It is postulated that cellular repair mechanisms are operating to eliminate the memory affecting molecules. The overall contribution of several possible mechanisms to the observed cumulative and transient impairments in spatial and non-spatial memory is discussed.	en
heal.journalName	Electromagnetic Biology and Medicine	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	false