ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses

dc.contributor.author	Κολοβού, Βάνα	el
dc.contributor.author	Κολοβού, Γενοβέφα	el
dc.contributor.author	Μαρβάκη, Αποστολία	el
dc.contributor.author	Καρακώστα, Αγαθή	el
dc.contributor.author	Βασιλόπουλος, Γεώργιος Σ.	el
dc.date.accessioned	2015-04-27T15:13:19Z
dc.date.available	2015-04-27T15:13:19Z
dc.date.issued	2015-04-27
dc.identifier.uri	http://hdl.handle.net/11400/9076
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.lipidworld.com/	en
dc.subject	Proteins
dc.subject	Greece
dc.subject	Πρωτεϊνες
dc.subject	Ελλάδα
dc.title	ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses	en
heal.type	journalArticle
heal.classification	Metabolism
heal.classification	Nurses
heal.classification	Μεταβολισμός
heal.classification	Νοσηλευτές
heal.classificationURI	http://skos.um.es/unescothes/C02484
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85093349
heal.classificationURI	N/A-Μεταβολισμός
heal.classificationURI	N/A-Νοσηλευτές
heal.keywordURI	http://zbw.eu/stw/descriptor/17184-0
heal.contributorName	Καλογιάννη, Αντωνία	el
heal.contributorName	Δεγιάννης, Δημήτριος	el
heal.contributorName	Μαρβάκη, Χριστίνα	el
heal.contributorName	Δημόπουλος, Κωνσταντίνος, Α.	el
heal.identifier.secondary	DOI: 10.1186/1476-511X-10-56
heal.language	en
heal.access	free
heal.recordProvider	Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Νοσηλευτικής	el
heal.publicationDate	2011-04-13
heal.bibliographicCitation	Kolovou, V., Kolovou, G., Marvaki, A., Karakosta, A., Vasilopoulos, G., et al. (2011) ATP-binding cassette transporter A1 gene polymorphisms and serum lipid levels in young Greek nurses. "Lipids in Health and Disease", 10 (56). Available from: http://www.lipidworld.com/content/10/1/56 [Accessed: 27/04/2015].	en
heal.abstract	Objective: The ATP-binding cassette transporter A1 (ABCA1) is essential protein involved in lipid metabolism. The present study was undertaken to detect the possible association of polymorphisms in the ABCA1 gene [rs2230806 (R219K) and rs2230808 (R1587K)] and lipid profile in Greek young nurses. Methods: The study population consisted of 308 unrelated nurses who were genotyped and the ABCA1 polymorphisms were detected. Additionally, lipid profile [total cholesterol (TC), triglycerides (TGs), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and apolipoprotein (apo) A] was evaluated. Results: There was no difference in the genotypic and allelic frequencies of the R219K polymorphism according to lipid profile. The R1587K genotypes differed significantly according to TC, LDL-C and TGs concentration (p = 0.023, p = 0.014 and p = 0.047, respectively). Particularly, significant difference in TC, LDL-C and TGs concentration was detected between RK and RR genotypes (p = 0.006, p = 0.004, p = 0.014, respectively). Women with RK genotype compared to RR genotype had higher concentration of TGs (134.25 mg/dl vs 108.89 mg/dl, p = 0.014, respectively), total cholesterol (207.41 mg/dl vs 187.69 mg/dl, p = 0.006, respectively), and LDL-C (110.6 mg/dl vs 96.9 mg/dl, p = 0.004, respectively). Conclusions: These findings suggest that the R1587K polymorphism of ABCA1 gene was associated with lipid profile of Greek nurses. Women with RK genotype had higher TGs, total and LDL-C concentration compared to RR genotype. These observations may be significant in assessing the risk of CAD since a 1% change in LDL-C is associated with a 1% change of cardiovascular events. Also, TGs concentration were documented to play a significant role in women. However, this needs to be confirmed by larger studies.	en
heal.journalName	Lipids in Health and Disease	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true