Association of gender, ABCA1 gene polymorphisms and lipid profile in Greek young nurses

dc.contributor.author	Κολοβού, Βάνα	el
dc.contributor.author	Μαρβάκη, Αποστολία	el
dc.contributor.author	Καρακώστα, Αγαθή	el
dc.contributor.author	Βασιλόπουλος, Γεώργιος Σ.	el
dc.contributor.author	Καλογιάννη, Αντωνία	el
dc.date.accessioned	2015-04-27T15:45:28Z
dc.date.available	2015-04-27T15:45:28Z
dc.date.issued	2015-04-27
dc.identifier.uri	http://hdl.handle.net/11400/9081
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.lipidworld.com/	en
dc.subject	Protein
dc.subject	Greece
dc.subject	Gender
dc.subject	Πρωτείνες
dc.subject	Ελλάδα
dc.subject	Φύλο
dc.title	Association of gender, ABCA1 gene polymorphisms and lipid profile in Greek young nurses	en
heal.type	journalArticle
heal.classification	Metabolism
heal.classification	Nurses
heal.classification	Μεταβολισμός
heal.classification	Νοσηλευτές
heal.classificationURI	http://skos.um.es/unescothes/C02484
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85093349
heal.classificationURI	N/A-Μεταβολισμός
heal.classificationURI	N/A-Νοσηλευτές
heal.keywordURI	http://zbw.eu/stw/descriptor/17184-0
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh00002547
heal.contributorName	Μαυρογένη, Σοφία	el
heal.contributorName	Δεγιάννης, Δημήτριος	el
heal.contributorName	Μαρβάκη, Χριστίνα	el
heal.contributorName	Κολοβού, Γενοβέφα	el
heal.identifier.secondary	DOI: 10.1186/1476-511X-11-62
heal.language	en
heal.access	free
heal.recordProvider	Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Νοσηλευτικής	el
heal.publicationDate	2012
heal.bibliographicCitation	Kolovou, V., Marvaki, A., Karakosta, A., Vasilopoulos, G., Kalogianni, A., et al. (2012) Association of gender, ABCA1 gene polymorphisms and lipid profile in Greek young nurses. "Lipids in Health and Disease", 11 (62). Available from: http://www.lipidworld.com/content/11/1/62 [Accessed: 27/04/2015]	en
heal.abstract	Objective: One of the important proteins involved in lipid metabolism is the ATP-binding cassette transporter A1 (ABCA1) encoding by ABCA1 gene. In this study we evaluated the single nucleotide polymorphisms (SNPs) of ABCA1 gene. We analyzed SNPs in chromosome 9 such as rs2230806 (R219K) in the position 107620867, rs2230808 (R1587K) in the position 106602625 and rs4149313 (I883M) in the position 106626574 according to gender and lipid profile of Greek nurses. Methods: The study population consisted of 447 (87 men) unrelated nurses who were genotyped for ABCA1 gene polymorphisms. Additionally, lipid profile [total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol (LDL-C) and apolipoprotein A1] was evaluated. Results: The distribution of all three studied ABCA1 gene polymorphisms did not differ according to gender. However, only R219K genotype distribution bared borderline statistical significance (p = 0.08) between the two studied groups. Moreover, allele frequencies of R219K, R1587K and I88M polymorphisms did not differ according to gender. In general, blood lipid levels did not seem to vary according to ABCA1 gene polymorphisms, when testing all subjects or when testing only men or only women. However, a significant difference of LDL-C distribution was detected in all subjects according to R1587K genotype, indicating lower LDL-C levels with KK polymorphism (p = 0.0025). The above difference was solely detected on female population (p = 0.0053). Conclusions: The ABCA1 gene polymorphisms frequency, distribution and lipid profile did not differ according to gender. However, in the female population the KK genotype of R1587K gene indicated lower LDL-C levels. Further studies, involving a higher number of individuals, are required to clarify genes and gender contribution.	en
heal.journalName	Lipids in Health and Disease	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true