Effect of nicotinamide on C-peptide levels in insulin - dependent diabetes mellitus

dc.contributor.author	Γουρνή, Μαρίτσα	el
dc.contributor.author	Ρούπα-Δαριβάκη, Ζωή	el
dc.contributor.author	Μαρβάκη, Χριστίνα	el
dc.contributor.author	Αρδαβάνης, Αλέξανδρος	el
dc.contributor.author	Σωτηροπούλου, Πηνελόπη	el
dc.date.accessioned	2015-04-28T15:41:01Z
dc.date.issued	2015-04-28
dc.identifier.uri	http://hdl.handle.net/11400/9184
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://pharmakonpress.gr/	en
dc.subject	insulin-dependent diabetes mellitus
dc.subject	Diabetes
dc.subject	Ινσουλινοεξαρτώμενοι διαβητικοί
dc.subject	Διαβήτης
dc.title	Effect of nicotinamide on C-peptide levels in insulin - dependent diabetes mellitus	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Internal medicine
heal.classification	Ιατρική
heal.classification	Παθολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85067347
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Παθολογία
heal.keywordURI	http://lod.nal.usda.gov/32968
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85037456
heal.contributorName	Γουρνή, Παναγιώτα	el
heal.contributorName	Μπαρτσώκας, Χρήστος	el
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	forever
heal.recordProvider	Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Νοσηλευτικής	el
heal.publicationDate	2005
heal.bibliographicCitation	Gourni, M., Roupa, Z., Marvaki, C., Ardavanis, A., Sotiropoulou, P., et al (2005) Effect of nicotinamide on C-peptide levels in insulin-dependent diabetes mellitus. "Epitheorise Klinikes Farmakologias", 19 (1), p. 37-42. Available from: http://pharmakonpress.gr/?p=3255 [Accessed: 28/04/2015].	en
heal.abstract	The aim of this study is to assess the effect of nicotinamide to c-peptide levels in children during the first six weeks of insulin-dependent diabetes mellitus (IDDM). Thirty-eight children and adolescents, with recent diagnosis (≤ 6 weeks) of IDDM were studied. Patients were randomized in two groups. In Group A patients received insulin and placebo, while in group B insulin and nicotinamide. Serum c-peptide levels were measured at 0, 3, 6, 9 and 12 months. The total dose of insulin administered the day preceding each sampling was recorded. Results: there was a significant difference between the various average values of c-peptide levels during the second trimester with p=0.01 for group A and p=0.02 for group B. No statistically significant difference was found between the two groups. Similar findings were observed for insulin-dose. Toxicity was negligible and similar in both groups. In conclusion, the treatment of newly diagnosed IDDM with NA does not significantly affect c- peptide levels for a period of time exceeding 6 months. However, this small-size pilot study should be confirmed by a large randomized study with different design involving NA treatment before clinical IDDM.	en
heal.publisher	Πλέσσα, Ελένη Σ.	el
heal.journalName	Epitheorise Klinikes Farmakologias	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	false