Photostability of retinoids

dc.contributor.author	Παπαγεωργίου, Σπυρίδων	el
dc.contributor.author	Βαρβαρέσου, Αθανασία	el
dc.contributor.author	Χατζηαντωνίου, Σοφία	el
dc.contributor.author	Τσιριβάς, Ευθύμιος	el
dc.contributor.author	Δεμέντζος, Κωνσταντίνος	el
dc.date.accessioned	2015-04-29T14:14:55Z
dc.date.issued	2015-04-29
dc.identifier.uri	http://hdl.handle.net/11400/9254
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	pharmakonpress.gr	en
dc.subject	Καλλυντικά
dc.subject	Χημικά παρασκευάσματα
dc.subject	Φαρμακευτική
dc.subject	Chemical preparations
dc.subject	Pharmacy
dc.title	Photostability of retinoids	en
heal.type	journalArticle
heal.secondaryTitle	the influence of the container	en
heal.classification	Aesthetics
heal.classification	Cosmetics
heal.classification	Αισθητική
heal.classification	Κοσμητολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85001441
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85033139
heal.classificationURI	N/A-Αισθητική
heal.classificationURI	N/A-Κοσμητολογία
heal.contributorName	Παπαϊωάννου, Γεώργιος	el
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	forever
heal.publicationDate	2007-01-15
heal.bibliographicCitation	Papageorgiou, S., Varvaresou, A., Hatziantoniou, S., Tsirivas, E., Demetzos, C. et al. (2007) Photostability of retinoids: The influence of the container. "Review of Clinical Pharmacology and Pharmacokinetics", International Edition 21 (1), p.49-53	en
heal.abstract	Among the retinoids, which are important in modern therapy for dermatological treatment of wrinkled skin, retinol and retinyl palmitate are regarded desirable because of their lower irritating activity compared to retinoic acid. Since retinol is unstable in cosmetic preparations, retinyl palmitate and liposomal retinol are used to a great extent in modern cosmetology. The chemical nature of retinoids, consisting of polyunsaturated polar lipids, makes them able to interact with oxygen and UV or visible light to produce reactive oxygen species and free radicals. The great interest in evaluating the stability of retinyl palmitate and liposomal retinol under UV irradiation is due to the loss of potency and enhancement of toxicity of their degradation products. This study aims to evaluate the stability of O/N formulated retinol in the liposomal or palmitate ester form under long term UV irradiation and moreover to investigate, the protection that aluminum lacquered containers could offer to such cosmetic preparations during storage or transfer. Therefore, solutions with a concentration of 2 μg/ml of retinol in the liposomal or palmitate ester form were prepared, irradiated for 72 hours and analyzed spectrophotometrically (λmax = 325) at pre-determined times (t= 0, 24, 48 and 72 h) to detect changes of absorbance and peak structure. Additionally, aluminum lacquered tube containing the cream with a concentration of 2.5 % W/W Rovisome or 0.05 % N/N all trans retinyl palmitate was irradiated for 72 h. Solutions of the irradiated cream with a final concentration of 2 μg/ml of retinol or retinyl palmitate analyzed spectrophotometrically at pre-determined times (t= 0, 24, 48 and 72 h). Derivative UV spectrophotometic technique was utilised succesfully to overcome the problem of interference due to irrelevant spectral overlapping caused by excipient matrices present in cosmetic preparations. In conclusion, the palmitate ester is more photosensitive than liposomal retinol under 3 days UVB irradiation in cosmetic emulsions, a fact that is in accordance with the results reffering to short term experiments. The aluminum lacquered tube protects to a great extent retinyl palmitate and liposomal retinol from degradation upon long term UVB irradiation and therefore is appropriate for the storage of that 1nd of formulations.	en
heal.journalName	Review of Clinical Pharmacology and Pharmacokinetics	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	false