Association between the TaqIB
polymorphism in the cholesteryl ester transfer protein gene locus and postprandial plasma lipoprotein levels in heterozygotes for familial hypercholesterolemia

dc.contributor.author	Κολοβού, Γενοβέφα Δ.	el
dc.contributor.author	Αναγνωστοπούλου, Κατερίνα Κ.	el
dc.contributor.author	Κωστάκου, Π.	el
dc.contributor.author	Μαρβάκη, Χριστίνα	el
dc.contributor.author	Μίχας, Κωνσταντίνος	el
dc.date.accessioned	2015-04-29T14:45:57Z
dc.date.issued	2015-04-29
dc.identifier.uri	http://hdl.handle.net/11400/9259
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.degruyter.com/view/j/cclm	en
dc.subject	Cholesterol
dc.subject	Atherosclerosis
dc.subject	cholesteryl ester transfer protein
dc.subject	familial hypercholesterolemia
dc.subject	high density lipoprotein
dc.subject	postprandial hypertriglyceridemia
dc.subject	TaqIB polymorphism
dc.subject	Χοληστερόλη
dc.subject	Αθηροσκλήρωση
dc.subject	Πρωτεϊνες αίματος
dc.subject	Οικογενής υπερχοληστερολαιμία
dc.subject	Λιποπρωτεϊνες υψηλής πυκνότητας
dc.subject	Υπερτριγλυκεριδαιμία
dc.subject	Πολυμορφισμός TaqIB
dc.title	Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and postprandial plasma lipoprotein levels in heterozygotes for familial hypercholesterolemia	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Internal medicine
heal.classification	Ιατρική
heal.classification	Εσωτερική παθολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85067347
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Εσωτερική παθολογία
heal.keywordURI	http://skos.um.es/unesco6/320702
heal.keywordURI	http://lod.nal.usda.gov/146581
heal.keywordURI	http://lod.nal.usda.gov/44718
heal.contributorName	Μιχαϊλίδης, Δημήτρης, Π.	el
heal.contributorName	Κόκκινος, Διονύσης, Β.	el
heal.identifier.secondary	DOI: 10.1515/CCLM.2007.267
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	forever
heal.recordProvider	Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Νοσηλευτικής	el
heal.publicationDate	2007-09
heal.bibliographicCitation	Anagnostopoulou, K., Kostakou, P., Marvaki, C., Mihas, C., et al (2007) Association between the TaqIB polymorphism in the cholesteryl ester transfer protein gene locus and postprandial plasma lipoprotein levels in heterozygotes for familial hypercholesterolemia. "Clinical Chemistry and Laboratory Medicine (CCLM)", 45 (9), p. 1190-1198. Available from: http://www.degruyter.com/view/j/cclm.2007.45.issue-9/cclm.2007.267/cclm.2007.267.xml [Accessed: 29/04/2015].	en
heal.abstract	Background: We examined the influence of cholesteryl ester transfer protein TaqIB polymorphism on triglyceride (TG) response to an oral fat tolerance test (OFTT) in patients heterozygous for familial hypercholesterolemia (hFH). Methods: We genotyped 67 hFH patients (32 men and 35 postmenopausal women) who were subjected to an OFTT. Results: All B1 allele carriers had lower high-density lipoprotein cholesterol (HDL-C) levels (p=0.013) and higher postprandial TG response at 6 and 8 h (p=0.05 and p=0.04, respectively) compared to B2 allele carriers. Multiple regression analysis showed that in the hFH group with a positive response, the presence of the B2 allele was significantly related to lower levels of TG-area under the curve (AUC) (p<0.01) compared to B1, adjusting for age, gender and body mass index. In the hFH group with a negative response, although age and female gender had a significant effect on TG-AUC levels (p<0.01 for both), the allele type was not significantly related to the TG-AUC levels (p=0.99). Conclusions: B2 carriers had a lower postprandial TG response compared to B1 carriers. There were no differences in TG levels between B1 and B2 carriers in patients with a negative OFTT response. Therefore, at higher TG concentration, the B2 allele may protect against an exaggerated postprandial TG increase and subsequent lowering of HDL-C.	en
heal.publisher	Plebani, Mario	en
heal.journalName	Clinical Chemistry and Laboratory Medicine (CCLM)	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	false