Sex-associated effect of CETP and LPL polymorphisms on postprandial lipids in familial hypercholesterolaemia

dc.contributor.author	Αναγνωστοπούλου, Κατερίνα, Κ.	el
dc.contributor.author	Κολοβού, Γενοβέφα Δ.	el
dc.contributor.author	Κωστάκου, Πέγκυ, Μ.	el
dc.contributor.author	Μίχας, Κωνσταντίνος	el
dc.contributor.author	Χατζηγεωργίου, Γεώργιος	el
dc.date.accessioned	2015-04-29T15:14:41Z
dc.date.available	2015-04-29T15:14:41Z
dc.date.issued	2015-04-29
dc.identifier.uri	http://hdl.handle.net/11400/9263
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.lipidworld.com/	en
dc.subject	Internal medicine
dc.subject	Proteins
dc.subject	Εσωτερική παθολογία
dc.subject	Πρωτεϊνες
dc.title	Sex-associated effect of CETP and LPL polymorphisms on postprandial lipids in familial hypercholesterolaemia	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Sex differences
heal.classification	Ιατρική
heal.classification	Διαφορές φύλου
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh2001008761
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Διαφορές φύλου
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85067347
heal.contributorName	Μαρβάκη, Χριστίνα	el
heal.contributorName	Δεγιάννης, Δημήτριος	el
heal.contributorName	Μιχαϊλίδης, Δημήτριος, Π.	el
heal.contributorName	Κόκκινος, Διονύσης, Β.	el
heal.identifier.secondary	DOI: 10.1186/1476-511X-8-24
heal.language	en
heal.access	free
heal.recordProvider	Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Νοσηλευτικής	el
heal.publicationDate	2009
heal.bibliographicCitation	Anagnostopoulou, K., Kolovou, G., Kostakou, P., Mihas, C., Papageorgiou, G., et al. (2009) Sex-associated effect of CETP and LPL polymorphisms on postprandial lipids in familial hypercholesterolaemia. "Lipids in Health and Disease", 8 (24), p. 1-14. Available from: http://www.lipidworld.com/content/8/1/24 [Accessed: 29/04/2015]	en
heal.abstract	Background: This study assessed the gender-specific influence of the cholesteryl ester transfer protein (TaqIB, I405V) and lipoprotein lipase (S447X) polymorphisms on the response to an oral fat tolerance test in heterozygotes for familial hypercholesterolaemia. Methods: We selected and genotyped 80 men and postmenopausal women heterozygous for familial hypercholesterolaemia (main group) as well as 11 healthy control subjects. Patients were subgrouped based on their response to oral fat tolerance test. The oral fat tolerance test was defined as pathological when postprandial triglyceride concentration was higher than the highest triglyceride concentration observed in healthy subjects (220 mg/dl) at any time (2, 4, 6 or 8 h). Results: In the pathological subgroup, men had significantly higher incremental area under the curve after oral fat tolerance test than postmenopausal women. Furthermore, multivariate analysis revealed a gender association of TaqIB and I405V influence on postprandial lipaemia in this subgroup. Conclusion: In conclusion, it seems that gender and TaqIB polymorphism of the cholesteryl ester transfer protein gene were both associated with the distribution of triglyceride values after oral fat tolerance test, only in subjects with a pathological response to oral fat tolerance test. Specifically, men carrying the B2 allele of the TaqIB polymorphism showed a higher postprandial triglyceride peak and a delayed return to basal values compared with women carrying B2. However, further investigations in larger populations are required to replicate and confirm these findings.	en
heal.publisher	UND Life Sciences, United States of America	en
heal.journalName	Lipids in Health and Disease	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true