New methods to protect skin from photodamage and reactive oxygen species (ROS) generation are necessary, since sunscreens do not provide full spectral protection against UV light Additionally, sunscreen ingredients may become ROS themselves, when activated by UV irradiation, and sunscreen chemicals may be absorbed into skin to potentially cause harm. Therefore, apart from using sunscreens to diminish the intensity of UV radiation reaching, the development of novel strategies to prevent ROS from reacting with biomolecules is a further valuable approach in limiting UV-induced skin damage. This presentation briefly reviews the most common topical antioxidants used in cosmetology. Vitamin C, vitamin E, ubiquinone, superoxide dismutase, peroxidase rich fennel seed extract (Foeniculum vulgare), selenium, silymarin, soy isoflavones, green tea polyphenols, melatonin and CM-glucan are the topical antioxidants included in this review.