The influence of the addition of melatonin to a magnesium ascorbyl phosphate - containing formulation on the mechanical properties of human skin

dc.contributor.author	Βαρβαρέσου, Αθανασία	el
dc.contributor.author	Τσαουλά, Ελεάνα	el
dc.contributor.author	Τσιριβάς, Ευθύμιος	el
dc.date.accessioned	2015-04-29T15:55:19Z
dc.date.issued	2015-04-29
dc.identifier.uri	http://hdl.handle.net/11400/9269
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://pharmakonpress.gr	en
dc.subject	Καλλυντικά
dc.subject	Δερματικές αντιδράσεις
dc.subject	Χημικά παρασκευάσματα
dc.subject	Cosmetics
dc.subject	Skin reactions
dc.subject	Chemical preparations
dc.title	The influence of the addition of melatonin to a magnesium ascorbyl phosphate - containing formulation on the mechanical properties of human skin	en
heal.type	journalArticle
heal.classification	Aesthetics
heal.classification	Dermatology
heal.classification	Αισθητική
heal.classification	Δερματολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85001441
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85037090
heal.classificationURI	N/A-Αισθητική
heal.classificationURI	N/A-Δερματολογία
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	forever
heal.publicationDate	2003-10-05
heal.bibliographicCitation	Varvaresou, A., Tsaoula, E. and Tsirivas, E. (2003) The influence of the addition of melatonin to a magnesium ascorbyl phosphate-containing formulation on the mechanical properties of human skin. "Review of Clinical Pharmacology and Pharmacokinetics", International Edition, 17 (3), p.177-181	en
heal.abstract	Certain vitamins and antioxidants have great popularity as primary ingredients in cosmetics. The magnesium salt of ascorbyl-2-phosphate (MAP) has been widely used as antioxidant and collagen promoting ingredient in cosmetic formulations. Melatonin (MELA) is known to be a potent antioxidant in vitro and in vivo. In this study we investigated the effect of the addition of melatonin to a MAP-containing formulation on the mechanical properties of human skin. A total of 10 healthy women aged 37-47 years, of phototype III and IV were studied. The MAP-MELA formulation was applied topically on the one side of the face twice daily for three weeks. The MAP formulation was applied on the other side of the face twice daily for the same period of time. The forehead was used as the untreated control area. Gross elasticity (Ua/Uf: 11.9%, p<0.05) and biological elasticity (Ur/Uf: 15.2%, p<0.005) were significantly improved for the MAP treated area. However topical application of MAP-MELA cream led to higher increase of these two elastic parameters (Ua/Uf: 16.7%, p<0.05) and (Ur/Uf: 23.7%, p<0.005). Regarding to viscoelastic to elastic ratio (Uv/Ue) a slightly higher increase was observed in the case of MAP-MELA treated site (11.4, p<0.005) in comparison with the MAP treated area (8.88 %, p<0.005).	en
heal.publisher	Pharmakon Press	el
heal.journalName	Review of Clinical Pharmacology and Pharmacokinetics	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	false