Derivatives of 5-Oxy-pyrido[2,3-b]quinoxaline-9-carboxylic acid

dc.contributor.author	Βαρβαρέσου, Αθανασία	el
dc.contributor.author	Ιακώβου, Κρίτων	el
dc.date.accessioned	2015-04-29T16:06:59Z
dc.date.available	2015-04-29T16:06:59Z
dc.date.issued	2015-04-29
dc.identifier.uri	http://hdl.handle.net/11400/9271
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://onlinelibrary.wiley.com	en
dc.source	http://onlinelibrary.wiley.com/doi/10.1002/jhet.5570390610/abstract	en
dc.subject	Καλλυντικά
dc.subject	Χημικά παρασκευάσματα
dc.subject	Cosmetics
dc.subject	Chemical preparations
dc.title	Derivatives of 5-Oxy-pyrido[2,3-b]quinoxaline-9-carboxylic acid	en
heal.type	journalArticle
heal.secondaryTitle	a tricyclic system useful for the synthesis of potential intercalators	en
heal.classification	Aesthetics
heal.classification	Chemistry
heal.classification	Αισθητική
heal.classification	Χημεία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85001441
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85022986
heal.classificationURI	N/A-Αισθητική
heal.classificationURI	N/A-Χημεία
heal.identifier.secondary	10.1002/jhet.5570390610
heal.language	en
heal.access	free
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθηνών. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Αισθητικής και Κοσμητολογίας	el
heal.publicationDate	2009-03-11
heal.bibliographicCitation	Varvaresou, A. and Iakovou, K. (2002) Derivatives of 5-Oxy-pyrido[2,3-b]quinoxaline-9-carboxylic acid: A tricyclic system useful for the synthesis of potential intercalators. "Journal of Heterocyclic Chemistry" 39 (6), p.1173-1176	en
heal.abstract	The synthesis of a new series of 5-oxy-pyrido[2,3-b]quinoxaline-9-carboxamides 4a-i and N1,N2-Bis(5-oxy-pyrido[2,3-b]quinoxaline-9-benzoyl)ethylenediamine (5) is reported starting from 2-chloro-3-nitropyri-dine. Fundamental steps of the synthetic pathway are i) preparation of 2-(3-nitro-pyridin-2-ylamino)benzoic acid (1) via copper-catalyzed condensation of 2-chloro-3-nitropyridine with o-anthranilic acid, ii) intramolecular cyclization of the acid 1 to 5-oxy-pyrido[2,3-b]quinoxaline-9-carboxylic acid (2b) upon treatment with concentrated sulfuric acid and oleum and iii) conversion of the acid 2 to the desired amides 4a-i and 5. Compounds 4a-i and 5 are oxygenated azaanalogs of phenazines, a wellknown series of intercalators with cytotoxic activity.	en
heal.publisher	Wiley	en
heal.journalName	Journal of Heterocyclic Chemistry	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	false