Novel series of DNA triple helix-binding ligands

dc.contributor.author	Fox, Keith R.	en
dc.contributor.author	Thurston, David E.	en
dc.contributor.author	Jenkins, Terence C.	en
dc.contributor.author	Βαρβαρέσου, Αθανασία	el
dc.contributor.author	Τσοτίνης, Ανδρέας	el
dc.contributor.author	Σιάτρα - Παπασταϊκούδη, Θεοδώρα	el
dc.date.accessioned	2015-04-30T13:35:53Z
dc.date.available	2015-04-30T13:35:53Z
dc.date.issued	2015-04-30
dc.identifier.uri	http://hdl.handle.net/11400/9321
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.sciencedirect.com	en
dc.source	http://www.sciencedirect.com/science/article/pii/S0006291X9691089X	en
dc.subject	Έλικα DNA
dc.subject	Βιολογία
dc.subject	DNA helix
dc.subject	Biology
dc.title	Novel series of DNA triple helix-binding ligands	en
heal.type	journalArticle
heal.classification	Aesthetics
heal.classification	Biochemistry
heal.classification	Αισθητική
heal.classification	Βιοχημεία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85001441
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85014171
heal.classificationURI	N/A-Αισθητική
heal.classificationURI	N/A-Βιοχημεία
heal.identifier.secondary	10.1006/bbrc.1996.1089
heal.language	en
heal.access	campus
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθηνών. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Αισθητικής και Κοσμητολογίας	el
heal.publicationDate	1996-07-25
heal.bibliographicCitation	Fox, K.R., Thurston, D.E., Jenkins, T.C., Varvaresou, A., Tsotinis, A., et al. (1996) Novel series of DNA triple helix-binding ligands. "Biochemical and Biophysical Research Communications" 224 (3), p.717-720	en
heal.abstract	We have examined the effect of a series of substituted imidazothioxanthones on the stability of an intermolecular DNA triple helix by DNase I footprinting. We find that several of these compounds promote the formation of a complex between T5C5and the target site A6G6·C6T6, suggesting that they bind specifically to triplex DNA. The only inactive derivative lacked a protonatable function in the side chain, suggesting that this is an essential feature for triplex stabilization. These compounds, which are amongst the first triplex-binding ligands which possess an uncharged chromophore, are selective for the T·AT rather than the C+·GC triplet.	en
heal.publisher	Elsevier	en
heal.journalName	Biochemical and Biophysical Research Communications	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	false