Efficacy and tolerance study of an oligopeptide with potential anti-aging activity

dc.contributor.author	Βαρβαρέσου, Αθανασία	el
dc.contributor.author	Παπαγεωργίου, Σπυρίδων	el
dc.contributor.author	Πρωτόπαπα, Ευαγγελία Ε.	el
dc.contributor.author	Κατσαρού, Αλεξάνδρα	el
dc.date.accessioned	2015-04-30T15:40:42Z
dc.date.available	2015-04-30T15:40:42Z
dc.date.issued	2015-04-30
dc.identifier.uri	http://hdl.handle.net/11400/9328
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.scirp.org	en
dc.source	http://www.scirp.org/journal/PaperInformation.aspx?PaperID=16474#.VUJL05PzyQk	en
dc.subject	Καλλυντικά
dc.subject	Ολιγοπεπτίδια
dc.subject	Αντιγήρανση
dc.subject	Cosmetics
dc.subject	Δερματική αντίδραση
dc.subject	Anti-aging
dc.subject	Skin reaction
dc.title	Efficacy and tolerance study of an oligopeptide with potential anti-aging activity	en
heal.type	journalArticle
heal.classification	Aesthetics
heal.classification	Dermatology
heal.classification	Αισθητική
heal.classification	Δερματολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85001441
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85037090
heal.classificationURI	N/A-Αισθητική
heal.classificationURI	N/A-Δερματολογία
heal.identifier.secondary	10.4236/jcdsa.2011.14020
heal.language	en
heal.access	free
heal.publicationDate	2011-12
heal.bibliographicCitation	Varvaresou, Α., Papageorgiou, S., Protopapa, E. and Katsarou, A. (2011) Efficacy and tolerance study of an oligopeptide with potential anti-aging activity. "Cosmetics, Dermatological Sciences and Applications" 1 (4), p.133-140	en
heal.abstract	Background Oligopeptide-20 acts as positive regulator of cell proliferation and increases collagen and hyaluronic acid levels in keratinocyte and fibroblast cultures. Methods After randomization half the face of twenty volunteers was treated twice daily for two months with the oligopeptide-20 cream (0.003% w/w, 300 ppm) and the other half with the vehicle. Skin bioengineering was used to estimate the effects on human skin. Results The average number and width of wrinkles (Sew, 11.7%, p < 0.05) and cyclic average roughness (cR3, 12.2%, p < 0.005) were improved. Sesc parameter, indicative of stratum corneum dehydration was affected almost equally by the oligopeptide and the vehicle cream (p < 0.1). Volunteers noted statistically significant improvement regarding fine wrinkles and skin brightness on the peptide treated side, whereas the skin smoothness was improved on both sides. No significant changes in pigmentation measured by Mexameter were recorded. No significant changes in transepidermal water loss values were demonstrated, indicating oligopeptide-20 does not affect the skin barrier. No serious adverse or side effects were observed. Additionally, the oligopeptide cream was not irritant according to 48 hr semi-occluded patch test. Conclusion Oligopeptide-20 could be a useful and safe ingredient of anti-aging cosmetics.	en
heal.publisher	Scientific Research	en
heal.journalName	Cosmetics, Dermatological Sciences and Applications	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true