Associations of xenobiotic-metabolizing enzyme genotypes PON1Q192R, PON1L55M and CYP1A1*2A MspI with pathological symptoms of a rural population in south Greece

dc.contributor.author	Τσατσάκης, Αριστείδης Μ.	el
dc.contributor.author	Ανδρουτσόπουλος, Βασίλης Π.	el
dc.contributor.author	Ζαφειρόπουλος, Αλξέξανδρος	el
dc.contributor.author	Μπαμπάτσικου, Φωτούλα Π.	el
dc.contributor.author	Αλεγάκης, Θανάσης	el
dc.date.accessioned	2015-04-30T16:17:42Z
dc.date.issued	2015-04-30
dc.identifier.uri	http://hdl.handle.net/11400/9331
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://informahealthcare.com/journal/xen	en
dc.subject	Diseases
dc.subject	Paraoxonase
dc.subject	cytochrome P450 CYP1A1
dc.subject	Polymorphisms
dc.subject	Organophosphate pesticides
dc.subject	Associations
dc.subject	Παραοξονάση 1
dc.subject	Κυτοχρώμα P450 CYP1A1
dc.subject	Πολυμορφισμοί
dc.subject	Οργανοφωσφορικά παρασιτοκτόνα
dc.subject	Οργανοχλωριωμένα φυτοφάρμακα
dc.subject	Ενώσεις
dc.title	Associations of xenobiotic-metabolizing enzyme genotypes PON1Q192R, PON1L55M and CYP1A1*2A MspI with pathological symptoms of a rural population in south Greece	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Internal medicine
heal.classification	Ιατρική
heal.classification	Εσωτερική παθολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85067347
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Εσωτερική παθολογία
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85038411
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh2002008729
heal.contributorName	Διαλυνά, Ιωάννα	el
heal.contributorName	Τζατζαράκης, Μανώλης, Ν.	el
heal.contributorName	Κουτής, Χαρίλαος, Κ.	el
heal.identifier.secondary	DOI: 10.3109/00498254.2011.590545
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	forever
heal.recordProvider	Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Νοσηλευτικής	el
heal.publicationDate	2011-10
heal.bibliographicCitation	Tsatsakis, A., Androutsopoulos, V., Zafiropoulos, A., Babatsikou, F., Alegakis, T., et al. (2011) Associations of xenobiotic-metabolizing enzyme genotypes PON1Q192R, PON1L55M and CYP1A1*2A MspI with pathological symptoms of a rural population in south Greece. "Xenobiotica", 41 (10), p. 914-925. Available from: http://informahealthcare.com/doi/abs/10.3109/00498254.2011.590545 [Accessed: 30/04/2015].	en
heal.abstract	Paraoxonases and cytochromes P450 constitute two major classes of xenobiotic-metabolizing enzymes involved in the detoxification of pesticide chemicals. In this study, we examined the distribution of two common genetic polymorphisms of the paraoxonase 1 gene and one common polymorphism of the CYP1A1 gene, in relation to pathological diseases occurring in a rural population. Blood and hair samples were collected from 220 participants of an agricultural cohort in the south of Greece for genotype and pesticide analysis. Demographic information and disease status of the participants was obtained by questionnaire, medical examination and medical record. Organochlorine pesticides and metabolites (DDTs, HCHs) were extracted from hair and analyzed using gas chromatography combined with mass spectrometry techniques. Our results indicate exposure of the rural population of Amaliada to organophosphate and past exposure to organochlorine pesticides. Genotypic analysis of PON1Q192R, PON1L55M and CYP1A1*2A MspI polymorphisms was performed using PCR-RFLP. The PON1 192R and 55M alleles absence was significantly associated with hypertension (OR: 2.59; 95% CI: 1.10–6.09) and hepatitis (OR: 21.43; 95% CI: 2.53–181.50), respectively, as indicated from backward logistic regression. Although the presence of PON1 192R allele significantly affected the occurrence of prostate hyperplasia (OR: 0.35; 95% CI: 0.03–0.40), no associations were obtained between the paraoxonase serum activity or the CYP1A1 genotype and the disease status.	en
heal.publisher	Ioannides, Costas	en
heal.journalName	Xenobiotica	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	false