Difference in control recovery in interlaboratory quality control schemes for immunoassays

dc.contributor.author	Ευαγγελόπουλος, Άγγελος	el
dc.contributor.author	Κολλημένου, Π.	el
dc.contributor.author	Βαλλιανού, Ν.	el
dc.contributor.author	Καρκαλούσος, Πέτρος	el
dc.date.accessioned	2015-05-03T10:38:28Z
dc.date.issued	2015-05-03
dc.identifier.uri	http://hdl.handle.net/11400/9538
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.bclf.info/	en
dc.source	http://users.teiath.gr/petef/Web_CV/Presentations/Pre_Matrix_Attalya_2007.htm	el
dc.subject	Medical laboratory technology
dc.subject	Quality control
dc.subject	Quality Control Service
dc.subject	Τεχνολογία ιατρικών εργαστηρίων
dc.subject	Έλεγχος ποιότητας
dc.subject	Υπηρεσία ελέγχου ποιότητας
dc.title	Difference in control recovery in interlaboratory quality control schemes for immunoassays	en
heal.type	conferenceItem
heal.classification	Medicine
heal.classification	Technology
heal.classification	Ιατρική
heal.classification	Τεχνολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://zbw.eu/stw/descriptor/10470-6
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Τεχνολογία
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh86002225
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh00005852
heal.dateAvailable	10000-01-01
heal.language	en
heal.access	forever
heal.recordProvider	Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων	el
heal.publicationDate	2007
heal.bibliographicCitation	Evaggelopoulos, A., Kollimenou, P., Vallianou, N. and Karkalousos, P. (2007) Difference in control recovery in interlaboratory quality control schemes for immunoassays. In "15th Balkan Conference of Clinical Chemistry". Attalya: Balkan Clinical Laboratory Federation.	en
heal.abstract	Introduction: Roche Diagnostics runs a quality control scheme named QCS (Quality Control Service). QCS is a combination of internal and external quality control. Both procedures use the same data getting from analyzers. In this scheme Roche considered the problem of matrix effect. Matrix effect is the difference between a human sample and the corresponding control sample. Purpose: The detection of matrix effect and the institution of corrective actions in order to prevent this phenomenon on the future. Material - Method: As experimental materials were used the QCS’s control samples (PCU QCS 10651257/922 and PCTM QCS 10651265/922). These control specimens (PreciControls) were analyzed on the analyzers Roche/Hitachi Elecsys 1010 and 2010. Both analyzers use the technology of electrochemiluminescense and they measure a large variety analytes. The statistical analysis and storage were done with the use of program QCS Easy 4. Results: Statistical important differences were found between the results of human and control samples. These findings reveal the following: Roche determine its analytes on PreciControls as well as on human serum pools. These pools are stored in such conditions that retain their substances steady for a long time. On the other hand Roche determine the consensus mean of PreciControls before their posting to its customers. Although PreciControls are analyzed in referral laboratories, Roche noticed differences when different reagent’s lots were used for the determination of the same PreciControl’s lot. There is no any similar difference between different reagent’s lots and the same human pool. Discusion: The explanation of these differences lies in the matrix effect. It seems that the conservatives and the additives which are added in the serum change the protein structure, especially the antigen chemical affinity. Conclusion: Because of the matrix effect Roche proposes that the interlaboratory comparisons must refer not only in a certain control serum but in a combination of control serum and reagent lot.	en
heal.publisher	Balkan Clinical Laboratory Federation	en
heal.fullTextAvailability	false
heal.conferenceName	15th Balkan Conference of Clinical Chemistry	en
heal.conferenceItemType	abstract