Anticancer and chemopreventing natural products

dc.contributor.author	Καρίκας, Γεώργιος-Αλβέρτος	el
dc.date.accessioned	2015-05-07T20:58:00Z
dc.date.available	2015-05-07T20:58:00Z
dc.date.issued	2015-05-07
dc.identifier.uri	http://hdl.handle.net/11400/9902
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.ncbi.nlm.nih.gov/pubmed/21229622?dopt=AbstractPlus	en
dc.subject	χημειοθεραπεία κατά του καρκίνου
dc.subject	Φυσικά προϊόντα
dc.subject	Χημειοπροφύλαξη
dc.subject	θεραπευτικός
dc.subject	αντικαρκινικά
dc.subject	cancer chemotherapy
dc.subject	Natural products
dc.subject	Chemoprevention
dc.subject	Therapeutic use
dc.subject	Antineoplastic agents
dc.title	Anticancer and chemopreventing natural products	en
heal.type	journalArticle
heal.secondaryTitle	some biochemical and therapeutic aspects	en
heal.classification	Κλινική βιοχημεία
heal.classification	Καρκίνος
heal.classification	Clinical biochemistry
heal.classification	Cancer
heal.classificationURI	N/A-Κλινική βιοχημεία
heal.classificationURI	N/A-Καρκίνος
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85027062
heal.classificationURI	http://zbw.eu/stw/descriptor/18899-3
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85090252
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh99004975
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh2001008985
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85005714
heal.identifier.secondary	ISSN: 1107-0625
heal.language	en
heal.access	campus
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων	el
heal.publicationDate	2010-10
heal.bibliographicCitation	Karikas, G.A. (2010) Anticancer and chemopreventing natural products: some biochemical and therapeutic aspects. Journal of B.U.O.N. [Online] 15 (4), pp.627-638. Available from: http://www.ncbi.nlm.nih.gov [Accessed 07/05/2015]	en
heal.abstract	Natural products have afforded a rich source of compounds that have found many applications in cancer chemotherapy. Furthermore, the vast structural spectrum of natural compounds can provide "lead compounds" for therapeutic improvement by molecular modification. Over 70% of anticancer compounds are either natural products, or natural product-derived substances. On the other hand conjugation of toxic natural products to monoclonal antibodies or polymeric carriers can lead to more efficacious targeted therapies. Since less than 15% of higher plants have been systematically investigated, the natural products research towards chemotherapy requires further attention and multi-scientific collaboration. An enforcing application to chemotherapy, using natural products, is also chemoprevention. Apart from vegetables and fruit, more than 1,000 different phytochemicals are already proved to possess interesting chemopreventing activities. Effectiveness of chemopreventing agents reflects their ability to counteract certain upstream signals that leads to genotoxic damage, redox imbalances and other forms of cellular stress. Chemoprevention by edible phytochemicals is now considered to be an inexpensive, readily applicable, acceptable and accessible approach to cancer control and management. The present short review deals with a number of recent biochemical and therapeutic routes, concerning current approaches towards natural anticancer agents in clinical practice, new candidate oncotherapy drugs from plants, marine and microorganisms, as well as promising chemopreventing agents from nature.	en
heal.journalName	Journal of B.U.O.N.	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true