Early effects of sodium valproate monotherapy on serum paraoxonase/arylesterase activities

dc.contributor.author	Καρίκας, Γεώργιος-Αλβέρτος	el
dc.contributor.author	Σούλπη, Κλεοπάτρα	el
dc.contributor.author	Μπαρτζελιώτου, Αναστασία	el
dc.contributor.author	Ρεγκούτας, Σπύρος	el
dc.contributor.author	Θανοπούλου, Χριστίνα	el
dc.date.accessioned	2015-05-07T22:14:25Z
dc.date.available	2015-05-07T22:14:25Z
dc.date.issued	2015-05-08
dc.identifier.uri	http://hdl.handle.net/11400/9904
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.ncbi.nlm.nih.gov/pubmed/19016076	en
dc.subject	βαλπροϊκό οξύ
dc.subject	θεραπεία
dc.subject	δραστηριότητες των παιδιών
dc.subject	κατάσταση οξειδωτικού
dc.subject	βιοχημικές παραμέτρους
dc.subject	ένζυμα
dc.subject	Valproic acid
dc.subject	treatment
dc.subject	children activities
dc.subject	oxidant status
dc.subject	biochemical parameters
dc.subject	enzymes
dc.title	Early effects of sodium valproate monotherapy on serum paraoxonase/arylesterase activities	en
heal.type	journalArticle
heal.classification	Κλινική βιοχημεία
heal.classification	Παιδιατρική
heal.classification	Clinical biochemistry
heal.classification	Pediatrics
heal.classificationURI	N/A-Κλινική βιοχημεία
heal.classificationURI	N/A-Παιδιατρική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85027062
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85099185
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85141922
heal.contributorName	Παπαευαγγέλου, Βασιλική	el
heal.contributorName	Γιαννούλια Καραντάνα, Αγλαΐα	el
heal.contributorName	Παπασωτηρίου, Ιωάννης	el
heal.contributorName	Φύτου-Παλληκάρη, Αθηνά	el
heal.identifier.secondary	DOI: 10.1080/00365510802248051
heal.language	en
heal.access	campus
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων	el
heal.publicationDate	2009
heal.bibliographicCitation	Karikas, G.A., Schulpis, K.H., Bartzeliotou, A., Regoutas, S., Thanopoulou, C. et al. (2009) Early effects of sodium valproate monotherapy on serum paraoxonase/arylesterase activities. Scandinavian Journal of Clinical & Laboratory Investigation. [Online] 69 (1), pp.31-5. Available from: http://www.ncbi.nlm.nih.gov [Accessed 07/05/2015]	en
heal.abstract	Valproic acid (VPA) treatment and paraoxonase1/arylesterase (PON1/Aryl) activities are related to the production of free radicals. Our aim was to study the PON1/Aryl activities in children on VPA therapy. Thirty-two children with seizures and 30 healthy child volunteers took part. Ill children underwent the common laboratory tests, as well as total antioxidant status (TAS), total oxidant status (TOS), lipid profile, liver enzymes and PON1/Aryl activities pre- and post-60 days on VPA therapy (30 mg/kg/24 h), whereas the healthy children were tested just once. None of the studied biochemical parameters differed between volunteers and children with seizures pretreatment. Liver enzymes, lipids and TOS levels (124+/-30 versus 580+/-40 micromol/L; p<0.001) were significantly elevated, whereas the activities of PON1/Aryl (146+/-43 versus 118+/-40 U/mL/min 120+/-42 versus 98+/-38 KU/mL/min; p<0.01) and TAS levels (436+/-42 versus 288+/-39 micromol/L; p<0.001) were decreased in children after treatment. Additionally, strong negative correlations were found between PON1/Aryl activities, liver enzymes, TOS (r = -0.69) and VPA levels (r = -0.57), whereas PON1/Aryl activities correlated positively with TAS, HDL and Apo A-I in all groups. Serum PON1/Aryl activities were decreased after 60 days on VPA treatment, probably due to liver dysfunction and free radicals production by VPA, without excluding the possibility of a direct action of the drug on the enzymes.	en
heal.publisher	Informa Healthcare	en
heal.journalName	Scandinavian Journal of Clinical & Laboratory Investigation	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true