Alpha-tocopherol supplementation prevents the exercise-induced reduction of serum paraoxonase 1/arylesterase activities in healthy individuals

dc.contributor.author	Τσακίρης, Στυλιανός	el
dc.contributor.author	Καρίκας, Γεώργιος-Αλβέρτος	el
dc.contributor.author	Πάρθημος, Τ.	el
dc.contributor.author	Τσακίρης, Τ.	el
dc.contributor.author	Μπακογιάννης, Χ.	el
dc.date.accessioned	2015-05-07T22:49:25Z
dc.date.available	2015-05-07T22:49:25Z
dc.date.issued	2015-05-08
dc.identifier.uri	http://hdl.handle.net/11400/9905
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.nature.com/ejcn/journal/v63/n2/full/1602918a.html	en
dc.subject	παραοξονάση
dc.subject	αρυλεστεράσης
dc.subject	α-τοκοφερόλη
dc.subject	γυμναστική
dc.subject	οξίδωση
dc.subject	Paraoxonase
dc.subject	arylesterase
dc.subject	α-tocopherol
dc.subject	Exercise therapy
dc.subject	Oxidation, Physiological
dc.title	Alpha-tocopherol supplementation prevents the exercise-induced reduction of serum paraoxonase 1/arylesterase activities in healthy individuals	en
heal.type	journalArticle
heal.classification	Κλινική βιοχημεία
heal.classification	Ανθρώπινη φυσιολογία
heal.classification	Clinical biochemistry
heal.classification	Human physiology
heal.classificationURI	N/A-Κλινική βιοχημεία
heal.classificationURI	N/A-Ανθρώπινη φυσιολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85027062
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85062884
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh2002008729
heal.keywordURI	http://lod.nal.usda.gov/12712
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh00005704
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85096309
heal.contributorName	Σούλπη, Κλεοπάτρα	el
heal.identifier.secondary	DOI: 10.1038/sj.ejcn.1602918
heal.language	en
heal.access	campus
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων	el
heal.publicationDate	2009-02
heal.bibliographicCitation	Tsakiris, S., Karikas, G.A., Parthimos, T., Tsakiris, T., Bakogiannis, C. et al. (2009) Alpha-tocopherol supplementation prevents the exercise-induced reduction of serum paraoxonase 1/arylesterase activities in healthy individuals. European Journal of Clinical Nutrition. [Online] 63 (2). pp.215-221. Available from: http://www.nature.com [Accessed 07/05/2015]	en
heal.abstract	Objective: To investigate PON 1/Aryl activities in basketball players with or without α-T supplementation pre- and post-training. Vitamin E (α-tocopherol, α-T) reduces lipid peroxidation. Paraoxonase 1/arylesterase (PON 1/Aryl) activities are closely related to oxidation and atherogenesis. Subject/Methods: Blood was obtained from 10 players pre- (group A), post-exercise (group B) and after 1 month on α-T (200 mg per 24 h orally) supplementation pre- (group C) and post-exercise (group D). Lactate, pyruvate, muscle enzyme activities, creatine kinase, lactate dehydrogenase and total antioxidant status (TAS) were measured with commercial kits. Catecholamines and α-T were determined with high-performance liquid chromatography methods and PON 1/Aryl activities spectrophotometrically. Results: Lactate, pyruvate, muscle enzyme activities and catecholamines were increased (P<0.001) in all groups post-training. Alpha-T levels remained unaltered pre- vs post-exercise. TAS was decreased in all the groups post training. PON 1/Aryl activities were significantly decreased post-exercise (group B) (PON1: 65±12 U min−1 ml−1, Aryl: 58±14 KU min−1 ml−1) as compared to those pre-exercise (group A) (PON1: 142±16 U min−1 ml−1, Aryl: 114±12 KU min−1 ml−1, P<0.001). In contrast, the studied enzyme activities remained practically unaltered after α-T supplementation pre- vs post-training. Both enzyme activities positively correlated to TAS (r=0.60, P<0.001). Conclusions: Alpha-T supplementation may result in protection of the enzyme PON 1/Aryl activities from free radical production.	en
heal.journalName	European Journal of Clinical Nutrition	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true