The effect of diet on Paraoxonase 1/Arylesterase activities in patients with disorders of galactose metabolism

dc.contributor.author	Σούλπη, Κλεοπάτρα	el
dc.contributor.author	Καρίκας, Γεώργιος-Αλβέρτος	el
dc.contributor.author	Μπαρτζελιώτου, Αναστασία	el
dc.contributor.author	Παπακωνσταντίνου, Ευάγγελος Δ.	el
dc.contributor.author	Καλογεράκου, Μαρία	el
dc.date.accessioned	2015-05-08T00:08:50Z
dc.date.available	2015-05-08T00:08:50Z
dc.date.issued	2015-05-08
dc.identifier.uri	http://hdl.handle.net/11400/9908
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2265.2007.02946.x/abstract	en
dc.subject	επιδράσεις της δίαιτας
dc.subject	αντιαρτηριοσκληρωτικό ένζυμο
dc.subject	Παραοξονάση
dc.subject	Αρυλεστεράση
dc.subject	μεταβολισμός
dc.subject	γαλακτόζη
dc.subject	effects of diet
dc.subject	antiatherogenic enzyme
dc.subject	Paraoxonase
dc.subject	arylesterase
dc.subject	metabolism
dc.subject	galactose
dc.title	The effect of diet on Paraoxonase 1/Arylesterase activities in patients with disorders of galactose metabolism	en
heal.type	journalArticle
heal.classification	Κλινική βιοχημεία
heal.classification	Ενδοκρινολογία
heal.classification	Clinical biochemistry
heal.classification	Endocrinology
heal.classificationURI	N/A-Κλινική βιοχημεία
heal.classificationURI	N/A-Ενδοκρινολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85027062
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh2002006108
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh2002008729
heal.keywordURI	http://lod.nal.usda.gov/12712
heal.keywordURI	http://lod.nal.usda.gov/6219
heal.contributorName	Τσακίρης, Στυλιανός	el
heal.identifier.secondary	DOI: 10.1111/j.1365-2265.2007.02946.x
heal.language	en
heal.access	free
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων	el
heal.publicationDate	2007-11
heal.bibliographicCitation	Schulpis, K.H., Karikas, G.A., Bartzeliotou, A., Papakonstantinou, E.D., Kalogerakou, M. et al. (2007) The effect of diet on Paraoxonase 1/Arylesterase activities in patients with disorders of galactose metabolism. Clinical Endocrinology. [Online] 67 (5). pp.687-692. Available from: http://onlinelibrary.wiley.com [Accessed 07/05/2015]	en
heal.abstract	Objective To investigate the effects of diet on the antiatherogenic enzyme Paraoxonase 1/Arylesterase (PON1/Aryl) activities in patients with disorders of galactose metabolism. Patients and methods Eleven poorly dietary controlled children with classical galactosaemia (GALT deficiency), 7 with epimerase deficiency and 12 with duarte 1 variant ‘off diet’ underwent clinical and laboratory investigations before and after 10 days on galactose restricted diet whereas controls (N = 20) were examined once. Serum lipids, lipoproteins and apolipoprotein A1 (ApoA1) were measured with routine methods, PON1/Aryl activities and total antioxidant status (TAS) spectrophotometrically, and galactose-1-phosphate (Gal-1-P) enzymatically. Results Lipids, lipoproteins, ApoA1, PON1/Aryl, TAS remained unaltered in all groups, except in those with classical galactosaemia pre- versus postdiet. In patients with classical galactosaemia, TAS, PON1, Aryl (0·98 ± 0·2 mmol/l, 60 ± 12 U/min/ml, 56 ± 16 KU/min/ml, respectively) were significantly reduced prediet as compared with those postdiet (1·63 ± 0·2 mmol/l, 136 ± 15 U/min/ml, 112 ± 18 KU/min/ml, respectively; P < 0·001) and controls. The enzyme activities positively correlated with TAS (r = 0·56, P < 0·001) in all groups and negatively with Gal-1-P (r = –0·54, P < 0·001) in group with GALT deficiency. Conclusions Low TAS and high Gal-1-P levels may reduce PON1/Aryl activities. Patients with classical galactosaemia, when on strict diet, may benefit with a generous antiatherogenic capacity.	en
heal.journalName	Clinical Endocrinology	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true