Brain atrophy in children undergoing systemic chemotherapy for extracranial solid tumors

dc.contributor.author	Πρασόπουλος, Παναγιώτης Π.	el
dc.contributor.author	Κάβουρας, Διονύσης Α.	el
dc.contributor.author	Ευλογιάς, Νικόλαος	el
dc.contributor.author	Γκολφινόπουλος, Νικόλαος	el
dc.date.accessioned	2015-05-08T08:57:45Z
dc.date.available	2015-05-08T08:57:45Z
dc.date.issued	2015-05-08
dc.identifier.uri	http://hdl.handle.net/11400/9926
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1096-911X(199703)28:3%3C228::AID-MPO15%3E3.0.CO;2-A/abstract	en
dc.subject	Ccomputed tomography
dc.subject	Childhood cancer
dc.subject	Αξονική τομογραφία
dc.subject	Καρκίνος παιδικής ηλικίας
dc.title	Brain atrophy in children undergoing systemic chemotherapy for extracranial solid tumors	en
heal.type	journalArticle
heal.classification	Medicine
heal.classification	Oncology
heal.classification	Ιατρική
heal.classification	Ογκολογία
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh00006614
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85094724
heal.classificationURI	N/A-Ιατρική
heal.classificationURI	N/A-Ογκολογία
heal.identifier.secondary	DOI: 10.1002/(SICI)1096-911X(199703)28:3<228::AID-MPO15>3.0.CO;2-A
heal.language	en
heal.access	campus
heal.recordProvider	Τ.Ε.Ι. Αθήνας. Σχολή Τεχνολογικών Εφαρμογών. Τμήμα Μηχανικών Βιοϊατρικής Τεχνολογίας Τ.Ε.	el
heal.publicationDate	1997
heal.bibliographicCitation	Prassopoulos, P., Cavouras, D., Evlogias, N. and Golfinopoulos, S. (March 1997). Brain atrophy in children undergoing systemic chemotherapy for extracranial solid tumors. Medical and Pediatric Oncology. 28(3). pp. 228-233. Available from: http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1096-911X(199703)28:3%3C228::AID-MPO15%3E3.0.CO;2-A/abstract [Accessed 07/12/1998]	en
heal.abstract	It has been shown that intracthecal chemotherapy may cause brain damage, which can be depicted in neuroimaging studies. The aim of this work was to examine possible morphologic alterations in the brain of children with extracranial solid tumors, without CNS complications, treated with systemic chemotherapy. Brain CT images of 69 children with extracranial malignancies were reviewed and the extent of 12 CSF compartments was measured in 49 CT examinations performed during intravenously given chemotherapy and in 20 after therapy completion. Measurements were compared with corresponding normative data. About half of the children undergoing chemotherapy and half of the patients examined after treatment were found to have diffuse brain atrophy. Focal lesions that might be associated with therapy toxicity were not observed. Chemotherapy, even when administered via the systemic route, may cause brain damage, which is observed long after the end of treatment.	en
heal.publisher	Wiley-Liss, Inc	en
heal.journalName	Medical and Pediatric Oncology	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true