Lipids, lipoproteins, apolipoproteins, selected trace elements and minerals in the serum of children on valproic acid monotherapy

dc.contributor.author	Καρίκας, Γεώργιος-Αλβέρτος	el
dc.contributor.author	Σούλπη, Κλεοπάτρα	el
dc.contributor.author	Μπαρτζελιώτου, Αναστασία	el
dc.contributor.author	Καρακωνσταντάκης, Θεόδωρος	el
dc.contributor.author	Γεωργαλά, Σοφία	el
dc.date.accessioned	2015-05-08T18:38:28Z
dc.date.available	2015-05-08T18:38:28Z
dc.date.issued	2015-05-08
dc.identifier.uri	http://hdl.handle.net/11400/9982
dc.rights	Αναφορά Δημιουργού-Μη Εμπορική Χρήση-Όχι Παράγωγα Έργα 3.0 Ηνωμένες Πολιτείες	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/us/	*
dc.source	http://www.ncbi.nlm.nih.gov/pubmed/16700824?dopt=AbstractPlus	en
dc.subject	λιπίδια
dc.subject	λιποπρωτεΐνες
dc.subject	απολιποπρωτεϊνες
dc.subject	μέταλλα και ιχνοστοιχεία
dc.subject	βαλπροϊκό οξύ
dc.subject	μονοθεραπεία
dc.subject	ομάδα παιδιών
dc.subject	επίπεδα ορού
dc.subject	Lipids--Congresses
dc.subject	Lipoproteins
dc.subject	Apolipoproteins
dc.subject	minerals and trace elements
dc.subject	monotherapy
dc.subject	group of children
dc.subject	serum levels
dc.title	Lipids, lipoproteins, apolipoproteins, selected trace elements and minerals in the serum of children on valproic acid monotherapy	en
heal.type	journalArticle
heal.classification	Χημεία
heal.classification	Chemistry
heal.classification	Φαρμακευτική
heal.classification	Pharmacy
heal.classificationURI	N/A-Χημεία
heal.classificationURI	http://skos.um.es/unescothes/C00568
heal.classificationURI	N/A-Φαρμακευτική
heal.classificationURI	http://id.loc.gov/authorities/subjects/sh85100603
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh2009129842
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh85077309
heal.keywordURI	http://id.loc.gov/authorities/subjects/sh86003932
heal.contributorName	Καναβάκη, Ινώ	el
heal.contributorName	Δημητρίου, Ελισάβετ	el
heal.contributorName	Παπασωτηρίου, Ιωάννης	el
heal.identifier.secondary	DOI: 10.1111/j.1742-7843.2006.pto_402.x
heal.language	en
heal.access	free
heal.recordProvider	Τεχνολογικό Εκπαιδευτικό Ίδρυμα Αθήνας. Σχολή Επαγγελμάτων Υγείας και Πρόνοιας. Τμήμα Ιατρικών Εργαστηρίων	el
heal.publicationDate	2006-06
heal.bibliographicCitation	Karikas, G.A., Schulpis, K.H., Bartzeliotou, A., Karakonstantakis, T., Georgala, S. et al. (2006) Lipids, lipoproteins, apolipoproteins, selected trace elements and minerals in the serum of children on valproic acid monotherapy. Basic & Clinical Pharmacology & Toxicology. [Online] 98 (6), pp.599-603. Available from: http://www.ncbi.nlm.nih.gov [Accessed 08/05/2015]	en
heal.abstract	We evaluated the serum levels of lipids, lipoproteins, apolipoproteins, along with a number of minerals and trace elements such as Ca, Mg, Cu and Zn in a group of children after 6 months of valproic acid monotherapy. Thirty patients with seizures, mean age, 9.8±2.6 years and 79 healthy children (controls), mean age, 10.9±3.2 years, formed the two styd groups. The patient group was treated with valproic acid (27.9±14.8 mg/kg/24 hr). Patients underwent clinical and laboratory evaluations including liver function tests, NH3, lipid, mineral and selected trace element levels before and after six months on valproic acid treatment, whereas controls only one evaluation. Liver function data and NH3 levels were found to be elevated in the group of patients, whereas albumin level was reduced. Triglycerides, total cholesterol, HDL-C, apolipoprotein (ApoA)-1, Apo B and Ca concentrations were found relative to control values, LDL-C, VLDL-C, Mg, Cu, Zn, were measured significantly altered (P<0.0001) compared to controls. The ratios ApoA-1/ApoB, HDL-C/ApoA-1, LDL-C/Apo B, which were closely related to the size of LDL particles, where correlated with Zn/Cu (P<0.001). Serum lipid profile, especially LDL size, indirectly evaluated for the first time and metal levels were found to be significantly changed, after six months on valproic acid monotherapy, suggesting a possible risk of developing coronary heart disease. Since valproic acid is a long-term treatment, it could be recommended that the incorporation of measurements of lipids, lipoproteins, apolipoproteins and trace elements in the “follow up” laboratory testing could be a preventive measure.	en
heal.journalName	Basic & Clinical Pharmacology & Toxicology	en
heal.journalType	peer-reviewed
heal.fullTextAvailability	true